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Triple-Negative Breast Cancer clinical trials in Nashville, TN

28 studies for Triple-Negative Breast Cancer are looking for participants at sites in and around Nashville (within about 30 miles). Open a study to see who can join and how to contact the study team.

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A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • Tennessee Oncology, Nashville
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06270706

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • Sarah Cannon Research Institute, Nashville
  • Tennessee Oncology PLLC, Nashville
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06465069

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • Sarah Cannon Research Institute, Nashville
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors

RecruitingPhase 1
  • Sarah Cannon Research Institute (SCRI), Nashville
Ages 19 and older · All sexes · Updated Oct 1, 2026 · NCT06586957

Testing the Addition of Anti-Cancer Drug, ZEN003694 (ZEN-3694) and PD-1 Inhibitor (Pembrolizumab), to Standard Chemotherapy (Nab-Paclitaxel) Treatment in Patients With Advanced Triple-Negative Breast Cancer

RecruitingPhase 1
  • Vanderbilt Breast Center at One Hundred Oaks, Nashville
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT05422794

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

RecruitingObservational study
  • Vanderbilt University Medical Center, Nashville
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT04981119

A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

RecruitingPhase 3
  • SCRI Oncology Partners ( Site 7004), Nashville
  • Tennessee Oncology ( Site 0018), Nashville
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06841354

Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)

RecruitingPhase 3
  • One Oncology - Tennessee Oncology ( Site 0098), Nashville
  • SCRI Oncology Partners ( Site 7000), Nashville
  • Tennessee Oncology ( Site 0111), Nashville
  • and 1 more
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06393374

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

RecruitingPhase 3
  • SCRI Oncology Partners ( Site 7005), Nashville
  • Nashville General Hospital ( Site 0017), Nashville
  • Vanderbilt-Ingram Cancer Center ( Site 0038), Nashville
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06966700

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

RecruitingPhase 1
  • Sarah Cannon - Tennessee Oncology, Nashville
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05983432

Phase 1 Study of a Self-amplifying RNA Vaccine (ITI-5000) in Stage 2-3 Triple Negative Breast Cancer

RecruitingPhase 1
  • Sarah Cannon Research Institute, Nashville
Ages 18 and older · Women · Updated Sep 10, 2026 · NCT07652242

Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies

RecruitingObservational study
  • Nashville General, Nashville
Ages 18 to 99 · All sexes · Updated Sep 3, 2026 · NCT07211178

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

RecruitingPhase 1
  • Normunity Investigational Site, Nashville
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07182149

A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Vanderbilt University Medical Center, Nashville
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT04895709

SMP-3124LP in Adults With Advanced Solid Tumors

RecruitingPhase 1/2
  • SCRI Oncology Partners, Nashville
  • Vanderbilt-Ingram Cancer Center, Nashville
Ages 18 and older · All sexes · Updated Aug 12, 2026 · NCT06526819

Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)

RecruitingPhase 1/2
  • Sarah Cannon Research Institute at Tennessee Oncology, Nashville
  • Tennessee Oncology, Nashville
Ages 18 and older · All sexes · Updated Aug 4, 2026 · NCT05579366

A Phase 1 of CTX-8371 in Patients With Advanced Malignancies

RecruitingPhase 1
  • Tennessee Oncology, Nashville
Ages 18 and older · All sexes · Updated Jul 28, 2026 · NCT06150664

A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors

RecruitingPhase 1/2
  • Sarah Cannon Research Institute (SCRI), Nashville
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05377996

Circulating Tumor DNA to Guide Changes in Standard of Care Chemotherapy

RecruitingPhase 2
  • Vanderbilt University/Ingram Cancer Center, Nashville
Ages 18 and older · All sexes · Updated Jun 24, 2026 · NCT05770531

A Study of LY4175408 in Participants With Advanced Cancer

RecruitingPhase 1
  • Sarah Cannon Research Institute, Nashville
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT07046923

Study of XB010 in Subjects With Solid Tumors

RecruitingPhase 1
  • SCRI Oncology Partners, Nashville
Ages 18 and older · All sexes · Updated Jun 22, 2026 · NCT06545331

A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types

RecruitingPhase 1
  • SCRI Oncology Partners, Nashville
Ages 18 and older · All sexes · Updated Jun 18, 2026 · NCT07503808

Pilot Study of Bone Mineral Density Changes During Anti-PD-1 Immunotherapy

Recruiting
  • Vanderbilt-Ingram Cancer Center, Nashville
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT07555210

Atezolizumab + Sacituzumab Govitecan to Prevent Recurrence in TNBC (ASPRIA)

RecruitingPhase 2
  • Vanderbilt-Ingram Cancer Center, Nashville
Ages 18 and older · All sexes · Updated May 4, 2026 · NCT04434040

A Study of Sacituzumab Govitecan Given at an Alternative Dose and Schedule in Participants With Advanced Triple-Negative Breast Cancer

RecruitingPhase 1/2
  • SCRI Oncology Partners, Nashville
  • Tennessee Oncology, PLLC, Nashville
Ages 18 and older · All sexes · Updated Jan 30, 2026 · NCT06926920

Neoadjuvant Darolutamide Alone or in Combination With Standard Therapy for Stage II-IIIA, AR+, TNBC

RecruitingPhase 2
  • Vanderbilt University/Ingram Cancer Center, Nashville
Ages 18 and older · All sexes · Updated Oct 30, 2025 · NCT07016399

A Phase 2 Study of PCS6422 With Capecitabine in Patients With Advanced or Metastatic Breast Cancer

RecruitingPhase 2
  • SCRI Oncology Partners, Nashville
Ages 18 and older · All sexes · Updated Jun 19, 2025 · NCT06568692

Triple-Negative Breast Cancer trials in other cities

Other studies in Nashville

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.