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Esophageal Adenocarcinoma clinical trials in North Carolina
12 studies for Esophageal Adenocarcinoma are looking for participants at sites in North Carolina.
Cities in North Carolina
Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial
- Cone Health MedCenter Asheboro, Asheboro
- Cone Health Cancer Center at Alamance Regional, Burlington
- Southeastern Medical Oncology Center-Clinton, Clinton
- and 6 more
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT06203600mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma
- UNC Lineberger Comprehensive Cancer Center, Chapel Hill
- Southeastern Medical Oncology Center-Clinton, Clinton
- Southeastern Medical Oncology Center-Goldsboro, Goldsboro
- and 5 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05677490A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Nivolumab in Combination With Chemotherapy in Participants With Previously Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma (ROSETTA Gastric-204)
- University of North Carolina Medical Center, Chapel Hill
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07221149Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma
- Duke University Medical Center, Durham
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07603375Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms
- University of North Carolina at Chapel Hill, Chapel Hill
RecruitingHealthy volunteers welcome
Ages 50 and older · All sexes · Updated Sep 15, 2026 · NCT06687603Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's Esophagus
- UNC Lineberger Comprehensive Cancer Center, Chapel Hill
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT06732388Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia
- University of North Carolina School of Medicine, Chapel Hill
Recruiting
Ages 18 to 89 · All sexes · Updated Sep 11, 2026 · NCT05753748Sonesitatug Vedotin in Combination With Capecitabine With or Without Rilvegostomig in Participants With Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing Claudin18.2
- Research Site, Charlotte
- Research Site, Wilmington
- Research Site, Winston-Salem
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07431281Obeticholic Acid for Prevention in Barrett's Esophagus
- UNC Lineberger Comprehensive Cancer Center, Chapel Hill
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT04939051Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance
- University of North Carolina at Chapel Hill, Chapel Hill
Recruiting
Ages 18 to 89 · All sexes · Updated Jul 1, 2026 · NCT05530343First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors
- Research Site, Durham
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT07284186A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer
- Durham VA Medical Center, Durham, NC, Durham
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 5, 2025 · NCT05563766From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.