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Esophageal Cancer clinical trials recruiting in the U.S.
110 studies for Esophageal Cancer are recruiting participants at sites across the United States.
Early esophageal cancer does not have symptoms. Factors that increase risk include heavy drinking and smoking. Learn how you can reduce your risk.
Cities with the most studies
- Houston, TX36 studies
- Boston, MA23 studies
- New York City, NY22 studies
- Nashville, TN19 studies
- St. Louis, MO17 studies
- Pittsburgh, PA15 studies
- Los Angeles, CA15 studies
- Grand Rapids, MI14 studies
- Baldwin Park, CA14 studies
- Philadelphia, PA13 studies
- San Antonio, TX12 studies
- Dallas, TX11 studies
- Arlington, VA11 studies
- Chicago, IL11 studies
- Rochester, MN11 studies
- San Diego, CA10 studies
- Durham, NC10 studies
- Cleveland, OH10 studies
- Portland, OR10 studies
- Washington, DC9 studies
- Denver, CO9 studies
- Atlanta, GA9 studies
- Detroit, MI9 studies
- Birmingham, AL8 studies
- Orlando, FL8 studies
- Milwaukee, WI8 studies
- Tampa, FL8 studies
- Minneapolis, MN8 studies
- Indianapolis, IN8 studies
- Toledo, OH7 studies
- Aurora, CO7 studies
- Edison, NJ7 studies
- Seattle, WA7 studies
- Santa Monica, CA7 studies
- Salt Lake City, UT7 studies
- Baltimore, MD7 studies
- Mountain View, CA7 studies
- Kansas City, MO7 studies
- Columbus, OH7 studies
- Queens, NY6 studies
By state
- Alabama8 studies
- Alaska4 studies
- Arizona11 studies
- Arkansas6 studies
- California41 studies
- Colorado19 studies
- Connecticut8 studies
- Delaware3 studies
- District of Columbia4 studies
- Florida33 studies
- Georgia11 studies
- Idaho3 studies
- Illinois15 studies
- Indiana12 studies
- Iowa6 studies
- Kansas8 studies
- Kentucky8 studies
- Louisiana5 studies
- Maine3 studies
- Maryland13 studies
- Massachusetts25 studies
- Michigan22 studies
- Minnesota19 studies
- Missouri20 studies
- Montana4 studies
- Nebraska7 studies
- New Jersey9 studies
- New Mexico6 studies
- New York28 studies
- North Carolina16 studies
- North Dakota4 studies
- Ohio22 studies
- Oklahoma8 studies
- Oregon11 studies
- Pennsylvania29 studies
- Rhode Island3 studies
- South Carolina7 studies
- South Dakota4 studies
- Tennessee21 studies
- Texas46 studies
- Utah8 studies
- Virginia16 studies
- Washington11 studies
- West Virginia3 studies
- Wisconsin16 studies
Recently updated studies
Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining
RecruitingObservational study
Ages 2 to 120 · All sexes · Updated Oct 2, 2026 · NCT00242723Distance-Based Exercise to Preserve Function and Prevent Disability
Recruiting
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07059884A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06465069Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07283939A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05319730Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06265285Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
RecruitingObservational studyHealthy volunteers welcome
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06760819A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06172478A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07090499A Phase 1, First-in-Human (FIH), Open-Label, Dose-Escalation and Dose Expansion Study of the Peptide Drug Conjugate (PDC), TS-104, as a Monotherapy in Subjects With Select Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07814248A Phase 1 Study of IM-1617 in Participants With Advanced Cancer
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07578571Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07603375Phase 1 Study of PF-08046033 in Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07519655DESTINY-PANTUMOUR04
RecruitingObservational study
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06123338Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06047379Pan-tumor MRD Study
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06605404sFOLFOXIRI in Advanced Gastroesophageal Cancer, (SAGE)
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT05332002Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551A Study of LY4257496 in Participants With Cancer (OMNIRAY)
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07114601A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213791Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05983432Prehabilitation in High-risk Oncologic Surgery
Recruiting
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07638410Using 18F-FAPI PET to Detect Metastatic Disease in Patients That Have Gastric or Esophageal Cancer.
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07217704From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.