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Kajian klinikal Kanser Kolorektal di Houston, TX
102 kajian untuk Kanser Kolorektal sedang mencari peserta di lokasi dalam dan sekitar Houston (dalam lingkungan kira-kira 30 batu). Buka kajian untuk melihat siapa yang layak menyertai dan cara menghubungi pasukan kajian.
Teks kajian rasmi (Bahasa Inggeris)
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A Study to Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil in Adult Participants With Refractory Metastatic Colorectal Cancer
Mengambil pesertaFasa 3
- The University of Texas MD Anderson Cancer Center /ID# 279865, Houston
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
Mengambil pesertaFasa 1/2
- The University of Texas MD Anderson Cancer Center, Houston
A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors
Mengambil pesertaFasa 1
- University of Texas MD Anderson Cancer Center, Houston
- NEXT Houston, Houston
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
Mengambil pesertaKajian pemerhatianSukarelawan sihat dialu-alukan
- UT MD Anderson Cancer Center, Houston
A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
Mengambil pesertaFasa 2
- The University of Texas MD Anderson Cancer Center - Texas Medical Center, Houston
177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors
Mengambil pesertaFasa 1/2
- MD Anderson Cancer Center, Houston
Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors
Mengambil pesertaFasa 1
- The University of Texas MD Anderson Cancer Center, Houston
Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
Mengambil pesertaFasa 1/2
- The Methodist Hospital Research Institute, Houston
- The University of Texas MD Anderson Cancer Center, Houston
A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors
Mengambil pesertaFasa 1
- ALX Center 5, Houston
Testing the Combination of Anti-Cancer Drugs, Botensilimab (AGEN1181) and Balstilimab (AGEN2034), After Standard Treatment for Colorectal Cancer, Combat Trial
Mengambil pesertaFasa 2
- UT MD Anderson Cancer Center, Houston
A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation
Mengambil pesertaFasa 1
- Research Site, Houston
A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal Cancer
Mengambil pesertaFasa 2
- The University of Texas MD Anderson Cancer Center, Houston
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
Mengambil pesertaFasa 3
- Oncology Consultants P.A., Houston
- Oncology Consultants P.A., Houston
- Texas Oncology - Gulf Coast, Houston
- dan 7 lagi
Spevatamig (PT886) as Monotherapy or in Combination With Chemo and/or Targeted Therapy and/or ICI, for the Treatment of Patients With Advanced Gastrointestinal Cancers, Including Gastric, Gastroesophageal Junction, Pancreatic Ductal or Biliary Tract Carcinomas (the TWINPEAK Study)
Mengambil pesertaFasa 1/2
- MD Anderson Cancer Center, GI Medical Oncology Dept, Houston
A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
Mengambil pesertaFasa 1/2
- University of Texas MD Anderson Cancer Center ( Site 0316), Houston
A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer
Mengambil pesertaFasa 1/2
- MD Anderson Cancer Center, Houston
Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
Mengambil pesertaFasa 1
- Research Site, Houston
A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors
Mengambil pesertaFasa 1
- MD Anderson Cancer Center, Houston
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
Mengambil pesertaFasa 3
- MD Anderson Cancer Center, Houston
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
Mengambil pesertaFasa 3
- MD Anderson Cancer Center, Houston
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
Mengambil pesertaFasa 2/3
- Baylor College of Medicine Medical Center, Houston
Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
Mengambil pesertaFasa 2
- Research Site, Houston
Testing the Addition of Anti-cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment, Cetuximab Plus Encorafenib, for Colorectal Cancer
Mengambil pesertaFasa 1
- UT MD Anderson Cancer Center, Houston
Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
Mengambil pesertaFasa 1/2
- MD Anderson, Houston
A Study of LY4257496 in Participants With Cancer (OMNIRAY)
Mengambil pesertaFasa 1
- MD Anderson Cancer Center, Houston
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
Mengambil pesertaFasa 1/2
- Baylor College of Medicine, Houston
- The University of Texas MD Anderson Cancer Center, Houston
A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
Mengambil pesertaFasa 1
- Baylor College of Medicine, Houston
A Study to Assess Safety and Efficacy of SOT109 in Patients With Advanced Unresectable or Metastatic Colorectal Cancer
Mengambil pesertaFasa 1/2
- NEXT Houston, Houston
A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations
Mengambil pesertaFasa 1/2
- The University of Texas MD Anderson Cancer Center - Texas Medical Center, Houston
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
Mengambil pesertaFasa 1/2
- MD Anderson Cancer Center, Houston
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
Mengambil pesertaFasa 3
- Md Anderson Cancer Center, Houston
Open-label Phase 1b Study of Ulixertinib and Cetuximab or Ulixertinib in Combination With Cetuximab and Encorafenib in Patients With Unresectable or Metastatic Colorectal Cancer Who Have Previously Received EGFR or BRAF-directed Therapy
Mengambil pesertaFasa 1
- M D Anderson Cancer Center, Houston
A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors
Mengambil pesertaFasa 1
- UT MD Anderson, Houston
Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
Mengambil pesertaFasa 3
- Clinical Study Site, Houston
- Clinical Study Site, Houston
A Study of Sofe-M in Participants With Selected Advanced Solid Tumors
Mengambil pesertaFasa 1
- The University of Texas - MD Anderson Cancer Center, Houston
A Study to Investigate CEA-PRIT 2.0 in Participants With Metastatic Colorectal Cancer (mCRC)
Mengambil pesertaFasa 1
- MD Anderson Cancer Center, Houston
FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors
Mengambil pesertaFasa 1
- M. D. Anderson Cancer Center, Houston
A Study of ERAS-0015 in Patients With Advanced or Metastatic Solid Tumors
Mengambil pesertaFasa 1
- The University of Texas MD Anderson Cancer Center, Houston
Regorafenib (Reg) and Lorigerlimab (Lor), RELO Regimen, in Treatment of High-risk Patients With Colorectal Cancer With Radiographic Occult Molecular Residual Disease After End of Established Definitive Therapy [ReLOAD Trial]
Mengambil pesertaFasa 2
- MD Anderson Cancer Center, Houston
Trial of AMB-05X for Patients With ctDNA(+) Colorectal Cancer After Curative-intent Treatment
Mengambil pesertaFasa 2
- The University of Texas MD Anderson Cancer Center, Houston
Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
Mengambil pesertaFasa 1/2
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors
Mengambil pesertaFasa 1
- MD Anderson Cancer Center, Houston
A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer
Mengambil pesertaFasa 2
- Research Site, Houston
FOG-001 in Locally Advanced or Metastatic Solid Tumors
Mengambil pesertaFasa 1/2
- The University of Texas MD Anderson Cancer Center, Houston
A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors
Mengambil pesertaFasa 1
- MD Anderson Cancer Center, Houston
A Study of MGC026 in Participants With Advanced Solid Tumors
Mengambil pesertaFasa 1
- The University of Texas MD Anderson Cancer Center, Houston
- University of Texas Health Science Center at Houston, Houston
A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors
Mengambil pesertaFasa 1/2
- The University of Texas, MD Anderson Cancer Center, Houston
Connecting Black Families in Houston, Texas to Hereditary Cancer Genetic Counseling, Genetic Testing, and Cascade Testing by Using a Simple Genetic Risk Screening Tool and Telegenetics
Mengambil pesertaSukarelawan sihat dialu-alukan
- MD Anderson Cancer Center, Houston
A Study of DM002 in Patients With Advanced Solid Tumors
Mengambil pesertaFasa 1/2
- The University of Texas, MD Anderson Cancer Center, Houston
IDOV-Immune for Advanced Solid Tumors
Mengambil pesertaFasa 1
- MD Anderson Cancer Center, Houston
Safety and Effectiveness Evaluation of the COLO-BT as an Alternative Treatment to the Ileostomy
Mengambil pesertaSukarelawan sihat dialu-alukan
- Baylor College of Medicine, Houston
Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors
Mengambil pesertaFasa 1/2
- MD Anderson Cancer Center, Houston
- MD Anderson Cancer Center, Houston
A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)
Mengambil pesertaFasa 1/2
- GSK Investigational Site, Houston
Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers
Mengambil pesertaFasa 1
- Uni Of TX MD Anderson Cancer Cntr, Houston
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
Mengambil pesertaFasa 1/2
- Oncology Consultants, Houston
Dual Administration Of Intraperitoneal And Intravenous TROP2-Directed CAR-NK With TGF-Beta Receptor 2 (TGFBR2) Knock Out (KO) Therapy For Colorectal Cancer-Related Peritoneal Carcinomatosis: A Phase 1/2 Trial ("Chip-CRC Trial")
Mengambil pesertaFasa 1/2
- MD Anderson Cancer Center, Houston
Phase 1 Study Of SAR445877 In Combination With FOLFOX6 And Bevacizumab As First-Line Treatment For Microsatellite Stable Metastatic Colorectal Cancer
Mengambil pesertaFasa 1
- MD Anderson Cancer Center, Houston
Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors
Mengambil pesertaFasa 1
- Investigative Site #129, Houston
A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
Mengambil pesertaFasa 1
- Md Anderson Cancer Center, Houston
A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors
Mengambil pesertaFasa 1
- The University of Texas - M.D. Anderson Cancer Center, Houston
- The University of Texas, MD Anderson Cancer Center - West Houston, Houston
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
Mengambil pesertaFasa 3
- The University of Texas MD Anderson Cancer Center, Houston
A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors
Mengambil pesertaFasa 1
- The University of Texas MD Anderson Cancer Center, Houston
An Investigational Scan (Intravoxel Incoherent Motion Diffusion Weighted Imaging) for the Evaluation of Colorectal Cancer Liver Metastases Treatment Response
Mengambil peserta
- M D Anderson Cancer Center, Houston
Association Between Health Care Provider (HCP)-Assessed ECOG Performance Status (PS) and Overall Survival, and Objectively Measure of Physical Activity (PA) Levels in Advance-cancer Patients"
Mengambil peserta
- M D Anderson Cancer Center, Houston
A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease
Mengambil pesertaFasa 2
- The University of Texas MD Anderson Cancer Center /ID# 273539, Houston
A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors
Mengambil pesertaFasa 2
- MD Anderson Cancer Center, Houston
A Trial to Evaluate the Safety and Activity of Fruquintinib in Minority Populations With Advanced, Previously Treated Colorectal Cancer
Mengambil pesertaFasa 4
- Oncology Consultants - Memorial City Location, Houston
- Baylor College of Medicine, Houston
Lead-212 PSV359 Therapy for Patients With Solid Tumors
Mengambil pesertaFasa 1/2
- MD Anderson Cancer Center, Houston
Initial Safety of SFM Plus OTOLoc for Creating Side-to-side or End-to-side Colorectal Anastomoses
Mengambil peserta
- University of Texas Health Science Center, Houston
A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors
Mengambil pesertaFasa 1/2
- MD Anderson Cancer Center, Houston
A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment Pumitamig (BNT327) and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer
Mengambil pesertaFasa 1/2
- The University of Texas MD Anderson Cancer Center, Houston
A Phase 1 Dose-escalation Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation
Mengambil pesertaFasa 1
- The University of Texas MD Anderson Cancer Center, Houston
A Multicenter Phase 1b/2 Study of Adagrasib, Cetuximab, and Cemiplimab for Metastatic Colorectal Cancer Harboring KRAS G12C Mutations
Mengambil pesertaFasa 1/2
- MD Anderson Cancer Center, Houston
A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types
Mengambil pesertaFasa 1
- MD Anderson, Houston
- NEXT Texas LLC - Houston, Houston
A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Efficacy of IDE574 Therapy in Adult Participants With Advanced Solid Tumors
Mengambil pesertaFasa 1
- NEXT Texas LLC - Houston, Houston
Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors
Mengambil pesertaFasa 2
- M D Anderson Cancer Center, Houston
A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors
Mengambil pesertaFasa 1
- MD Anderson Cancer Center, Houston
A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations
Mengambil pesertaFasa 1
- Research Site, Houston
KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors
Mengambil pesertaFasa 1
- MD Anderson Cancer Center, Houston
Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions
Mengambil pesertaFasa 1/2
- The University of Texas MD Anderson Cancer Center, Houston
Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors
Mengambil pesertaFasa 1
- University of Texas, MD Anderson Cancer Center, Houston
BBO-11818 in Adult Subjects With KRAS Mutant Cancer
Mengambil pesertaFasa 1
- The University of Texas MD Anderson Cancer Center, Houston
A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome
Mengambil pesertaFasa 2
- MD Anderson Cancer Center, Houston
A Study to Determine the Effect of CT3001 in Patients With Advanced Solid Tumors
Mengambil pesertaFasa 1/2
- MD Anderson Cancer Center, Houston
Minimal Residual Disease Assessment in Patients With Colorectal Cancer, the MiRDA-C Study
Mengambil pesertaKajian pemerhatian
- M D Anderson Cancer Center, Houston
Role of Diet on the Microbiome of the Digestive System
Mengambil pesertaKajian pemerhatian
- M D Anderson Cancer Center, Houston
Identifying Underserved Individuals inTexas With Hereditary Cancer Risk Using Mobile Mammography Units and Telegenetics.
Mengambil peserta
- M D Anderson Cancer Center, Houston
Precision-MRD: Prospective Observational Study of Biomarker-directed Systemic Therapy for Colorectal Cancer Patients With Minimal Residual Disease
Mengambil pesertaKajian pemerhatian
- MD Anderson Cancer Center, Houston
Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal Cancer
Mengambil pesertaFasa 2
- The University of Texas M. D. Anderson Cancer Center, Houston
Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
Mengambil pesertaFasa 1/2
- The University of Texas MD Anderson Cancer Center, Houston
A Study of TSN1611 Treating Patients With Advanced Solid Tumors Harboring KRAS G12D Mutation
Mengambil pesertaFasa 1/2
- MD Anderson Cancer Center, Houston
A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
Mengambil pesertaFasa 1/2
- MD Anderson Cancer Center, Houston
Phase I Trial of 5-Fluorouracil (5FU) -Based Therapy in Combination With Hydroxytyrosol (HT) in Patients With Advanced or Metastatic Colorectal Cancer
Mengambil pesertaFasa 1
- Houston Methodist., Houston
Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial
Mengambil peserta
- M D Anderson Cancer Center, Houston
A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy
Mengambil pesertaFasa 1/2
- MD Anderson Cancer Center, Houston
Trial of 5-Fluorouracil (5FU)-Based Therapy in Combination With Fruquintinib in Patients With Locally Advanced Unresectable or Metastatic Colorectal Cancer
Mengambil pesertaFasa 2
- Houston Methodist Neal Cancer Center, Houston
A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies
Mengambil pesertaFasa 1/2
- MD Anderson Cancer Center, Houston
A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors
Mengambil pesertaFasa 1/2
- The University of Texas MD Anderson Cancer Center, Houston
Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors
Mengambil pesertaFasa 1
- Baylor St. Luke's Medical Center, Houston
5-Fluorouracil/Leucovorin (5FU/LV) in Combination With Regorafenib in Patients With Metastatic Colorectal Cancer
Mengambil pesertaFasa 2
- Houston Methodist Neal Cancer Center, Houston
Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
Mengambil pesertaFasa 1
- MD Anderson Cancer Center, Houston
A Study of IBI363 in Subjects with Advanced Solid Malignancies
Mengambil pesertaFasa 2
- MD Anderson Cancer Center-University of Texas, Houston
- Oncology Consultants P.A., Houston
Kajian Kanser Kolorektal di bandar lain
- New York City, NY77 kajian
- Nashville, TN69 kajian
- Boston, MA63 kajian
- Los Angeles, CA59 kajian
- Arlington, VA52 kajian
- St. Louis, MO50 kajian
- San Antonio, TX46 kajian
- Philadelphia, PA44 kajian
- Grand Rapids, MI40 kajian
- Baldwin Park, CA38 kajian
- Seattle, WA34 kajian
- Tampa, FL33 kajian
Kajian lain di Houston
- Kanser Paru-paru Bukan Sel Kecil145 kajian
- Kanser Payudara126 kajian
- Kanser (semua jenis)121 kajian
- Kanser Metastatik104 kajian
- Kanser Ovari89 kajian
- Leukemia Mieloid Akut85 kajian
- Kanser Paru-paru78 kajian
- Kanser Prostat76 kajian
- Kanser Endometrium68 kajian
- Kanser Pankreas61 kajian
- Melanoma59 kajian
- Karsinoma Sel Skuamosa Kepala dan Leher47 kajian
Daripada ClinicalTrials.gov, data diperoleh pada 5 Okt 2026. Setiap kajian menetapkan kriteria kelayakannya sendiri; pasukan kajian menentukan siapa yang layak menyertai.