Home › Non-Small Cell Lung Cancer › NCT06040541
Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors
RecruitingPhase 1
Phase 1/1b, Multicenter, Open-Label, Study of RMC 9805 in Participants With Advanced KRASG 12D-Mutant Solid Tumors
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Pathologically documented, locally advanced or metastatic solid tumor with a KRAS G12D-mutation * Received and progressed or been intolerant to prior standard therapy (including targeted therapy) appropriate for tumor type and stage * ECOG performance status 0 or 1 * Adequate organ function Exclusion Criteria: * Primary central nervous system (CNS) tumors * Known or suspected leptomeningeal or active brain metastases or spinal cord compression * Known or suspected impairment of gastrointestinal function that may prohibit ability to swallow or absorb an oral medication * Participant was previously treated with an investigational KRAS G12D inhibitor, pan- or multi-RAS inhibitor, or had prior therapy with any direct RAS-targeted therapy (eg, degraders and inhibitors) Other inclusion/exclusion criteria may apply.
About the study
This study is to evaluate the safety and tolerability of RMC-9805 as monotherapy and in combination with RMC-6236 in adults with KRAS G12D-mutant solid tumors.
What is being tested
- RMC-9805 (drug)
- RMC-6236 (drug)
Sponsor: Revolution Medicines, Inc. · Participants: 604 · Started: Sep 7, 2023
Contact the study team
- Revolution Medicines, Inc. · Phone: 1-844-2-REVMED
Official record on ClinicalTrials.gov — NCT06040541
Locations in the U.S.
Conditions
- Non-Small Cell Lung Cancer
- Colorectal Cancer
- Lung Cancer
- Colon Cancer
- Pancreatic Cancer
- Metastatic Cancer
- Gastrointestinal Cancers
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.