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Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1

Phase 1/1b, Multicenter, Open-Label, Study of RMC 9805 in Participants With Advanced KRASG 12D-Mutant Solid Tumors

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* Pathologically documented, locally advanced or metastatic solid tumor with a KRAS G12D-mutation
* Received and progressed or been intolerant to prior standard therapy (including targeted therapy) appropriate for tumor type and stage
* ECOG performance status 0 or 1
* Adequate organ function

Exclusion Criteria:

* Primary central nervous system (CNS) tumors
* Known or suspected leptomeningeal or active brain metastases or spinal cord compression
* Known or suspected impairment of gastrointestinal function that may prohibit ability to swallow or absorb an oral medication
* Participant was previously treated with an investigational KRAS G12D inhibitor, pan- or multi-RAS inhibitor, or had prior therapy with any direct RAS-targeted therapy (eg, degraders and inhibitors)

Other inclusion/exclusion criteria may apply.

About the study

This study is to evaluate the safety and tolerability of RMC-9805 as monotherapy and in combination with RMC-6236 in adults with KRAS G12D-mutant solid tumors.

What is being tested

Sponsor: Revolution Medicines, Inc. · Participants: 604 · Started: Sep 7, 2023

Contact the study team

Official record on ClinicalTrials.gov — NCT06040541

Locations in the U.S.

CaliforniaUniversity of California, Davis Comprehensive Cancer Center, Sacramento
ConnecticutSmilow Cancer Hospital (Yale University), New Haven
FloridaFlorida Cancer Specialists, Sarasota
Lee Moffitt Cancer Center, Tampa
MarylandJohns Hopkins University, Baltimore
MassachusettsDana-Farber Cancer Institute, Boston
Massachusetts General Hospital, Boston
New YorkMemorial Sloan Kettering Cancer Center, New York
NYU Langone, New York
North CarolinaDuke Cancer Center, Durham
Carolina BioOncology Institute, Huntersville
OhioThe Christ Hospital, Cincinnati
TennesseeSarah Cannon Research Institute, Nashville
TexasSarah Cannon Research Institute at Mary Crowley, Dallas
University of Texas, MD Anderson Cancer Center, Houston
START, San Antonio
VirginiaNEXT Oncology Virginia, Fairfax

Conditions

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.