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Assessing Changes in Myocardial Tissue and Blood in Patients With Advanced Heart Disease
Assessing Changes in Myocardial Tissue and Blood in Patients With Advanced Heart Disease, Effects of Mechanical Unloading on Myocardial Function and Structure in Humans
Who can join
Ages 13 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * \>18 years of age diagnosed with heart failure undergoing either LVAD implantation or heart transplantation * 13 to 18 years of age, specifically, older children with heart failure whose body mass index is large enough to accommodate and LVAD Exclusion Criteria: * Neither patient nor patient representative understands spoken English * Neither patient nor patient's personal representative is willing to give written consent for participation.
About the study
Hypothesis:
Tissue and serum samples collected from end-stage heart failure patients receiving left ventricular assist device implantation (LVAD) or heart transplantation will provide information regarding the basic science of heart disease. Tissue and serum samples collected from a limited numbers of "healthy controls" (donor grafts that were not utilized for heart transplantation) will serve as a comparator in research database projects.
Design:
This is a registry project; there are no investigational treatments, drug or procedures associated with participation in registry activities. This project is an organized functional data and tissue data gathering and storing (database) endeavor with specific focus on the functional, structural, and molecular aspects of heart failure. Data collection will not immediately influence the course of treatment for any patient.
Sponsor: University of Utah · Participants: 300 · Started: 2008-09
Contact the study team
- John Kirk · Phone: 801-585-2944
- Stavros Drakos, M.D., Ph.D. · Phone: 801-585-2340
Official record on ClinicalTrials.gov — NCT01099982
Locations in the U.S.
| Utah | Intermountain Medical Center, Murray University of Utah Health Sciences Center, Salt Lake City VA Salt Lake City Health Care System, Salt Lake City |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.