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Heart Failure clinical trials recruiting in the U.S.

224 studies for Heart Failure are recruiting participants at sites across the United States.

Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.

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Recently updated studies

Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure

Recruiting
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT06552637

A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction

RecruitingPhase 1
Ages 18 to 100 · All sexes · Updated Nov 12, 2026 · NCT07465653

A Study to Evaluate the Safety and Efficacy of AC01 Compared to Placebo in Participants With Chronic Heart Failure

RecruitingPhase 2
Ages 18 to 85 · All sexes · Updated Nov 12, 2026 · NCT07584967

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06424288

Left vs Left Randomized Clinical Trial

Recruiting
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT05650658

PrEcision Pacing in HFpEF: the PEP-HFpEF Trial

Recruiting
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07864558

Barostim-Enabled NEurohormonal Intervention For Improving Treatment of Heart Failure

Recruiting
Ages 18 and older · All sexes · Updated Nov 9, 2026 · NCT07232030

Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

Recruiting
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT06526195

Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

RecruitingObservational study
All ages · All sexes · Updated Nov 4, 2026 · NCT00271180

SWITCH: Apixaban vs Vitamin K in HM3

RecruitingPhase 3
Ages 18 to 80 · All sexes · Updated Nov 4, 2026 · NCT07471139

A Study of LY3971297 in Participants With Heart Failure

RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Nov 4, 2026 · NCT07547540

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Nov 4, 2026 · NCT06736574

Evaluating a Digital Aid to Improve ICD Decisions

Recruiting
Ages 60 and older · All sexes · Updated Nov 3, 2026 · NCT07913204

ELEVATE-HFpEF Clinical Study

Recruiting
Ages 40 and older · All sexes · Updated Nov 3, 2026 · NCT06678841

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

RecruitingPhase 3
Ages 18 to 99 · All sexes · Updated Oct 29, 2026 · NCT07037459

Voice-based Outcome Identification and Clinical Evaluation in Heart Failure

RecruitingObservational study
Ages 22 and older · All sexes · Updated Oct 27, 2026 · NCT07870395

CCM OPEN HF Registry

RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT07112924

Cardiogenic Shock Working Group Registry

RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT04682483

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.