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Heart Failure clinical trials recruiting in the U.S.
224 studies for Heart Failure are recruiting participants at sites across the United States.
Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.
Cities with the most studies
- New York City, NY51 studies
- Boston, MA46 studies
- Dallas, TX42 studies
- Houston, TX35 studies
- Cleveland, OH31 studies
- Philadelphia, PA31 studies
- San Francisco, CA29 studies
- Chicago, IL28 studies
- Durham, NC25 studies
- Kansas City, MO25 studies
- St. Louis, MO24 studies
- Indianapolis, IN24 studies
- Atlanta, GA23 studies
- Baltimore, MD23 studies
- San Diego, CA22 studies
- Cincinnati, OH22 studies
- Minneapolis, MN22 studies
- Rochester, MN21 studies
- Ann Arbor, MI21 studies
- Los Angeles, CA20 studies
- Jacksonville, FL20 studies
- Washington, DC20 studies
- Nashville, TN19 studies
- Pittsburgh, PA18 studies
- Tampa, FL18 studies
- Salt Lake City, UT17 studies
- Aurora, CO17 studies
- Austin, TX17 studies
- Richmond, VA17 studies
- Portland, OR17 studies
- Orlando, FL16 studies
- Charleston, SC16 studies
- Seattle, WA16 studies
- Phoenix, AZ16 studies
- Arlington, VA15 studies
- Harrisburg, PA15 studies
- Milwaukee, WI15 studies
- Columbus, OH14 studies
- New Haven, CT14 studies
- Detroit, MI14 studies
By state
- Alabama20 studies
- Arizona29 studies
- Arkansas12 studies
- California66 studies
- Colorado22 studies
- Connecticut22 studies
- Delaware3 studies
- District of Columbia13 studies
- Florida51 studies
- Georgia26 studies
- Idaho6 studies
- Illinois44 studies
- Indiana30 studies
- Iowa10 studies
- Kansas17 studies
- Kentucky19 studies
- Louisiana17 studies
- Maine5 studies
- Maryland27 studies
- Massachusetts47 studies
- Michigan37 studies
- Minnesota43 studies
- Mississippi7 studies
- Missouri40 studies
- Nebraska19 studies
- Nevada4 studies
- New Jersey27 studies
- New Mexico5 studies
- New York57 studies
- North Carolina41 studies
- Ohio53 studies
- Oklahoma21 studies
- Oregon17 studies
- Pennsylvania45 studies
- Rhode Island3 studies
- South Carolina29 studies
- South Dakota15 studies
- Tennessee32 studies
- Texas67 studies
- Utah22 studies
- Vermont7 studies
- Virginia37 studies
- Washington25 studies
- West Virginia8 studies
- Wisconsin18 studies
Recently updated studies
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
RecruitingPhase 2/3
29 Days – 17 Years · All sexes · Updated Nov 13, 2026 · NCT05714085Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure
Recruiting
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT06552637A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction
RecruitingPhase 1
Ages 18 to 100 · All sexes · Updated Nov 12, 2026 · NCT07465653A Study to Evaluate the Safety and Efficacy of AC01 Compared to Placebo in Participants With Chronic Heart Failure
RecruitingPhase 2
Ages 18 to 85 · All sexes · Updated Nov 12, 2026 · NCT07584967A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06424288A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06935370INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery
Recruiting
Ages 18 to 80 · All sexes · Updated Nov 12, 2026 · NCT06965504Left vs Left Randomized Clinical Trial
Recruiting
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT05650658A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
Recruiting
Ages 18 to 85 · All sexes · Updated Nov 10, 2026 · NCT07214376PrEcision Pacing in HFpEF: the PEP-HFpEF Trial
Recruiting
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07864558Barostim-Enabled NEurohormonal Intervention For Improving Treatment of Heart Failure
Recruiting
Ages 18 and older · All sexes · Updated Nov 9, 2026 · NCT07232030Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
Recruiting
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT06526195Using Ultromics EchoGo HFpEF Algorithm to Identify and Treat High Heart Failure Risk in Patients With Type 2 Diabetes
Recruiting
All ages · All sexes · Updated Nov 5, 2026 · NCT06593314Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
RecruitingObservational study
All ages · All sexes · Updated Nov 4, 2026 · NCT00271180SWITCH: Apixaban vs Vitamin K in HM3
RecruitingPhase 3
Ages 18 to 80 · All sexes · Updated Nov 4, 2026 · NCT07471139A Study of LY3971297 in Participants With Heart Failure
RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Nov 4, 2026 · NCT07547540Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Nov 4, 2026 · NCT06736574Evaluating a Digital Aid to Improve ICD Decisions
Recruiting
Ages 60 and older · All sexes · Updated Nov 3, 2026 · NCT07913204Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure
Recruiting
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07069738ELEVATE-HFpEF Clinical Study
Recruiting
Ages 40 and older · All sexes · Updated Nov 3, 2026 · NCT06678841Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
RecruitingPhase 3
Ages 18 to 99 · All sexes · Updated Oct 29, 2026 · NCT07037459A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction
RecruitingPhase 3
Up to age 18 · All sexes · Updated Oct 27, 2026 · NCT07192952Voice-based Outcome Identification and Clinical Evaluation in Heart Failure
RecruitingObservational study
Ages 22 and older · All sexes · Updated Oct 27, 2026 · NCT07870395CCM OPEN HF Registry
RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT07112924Cardiogenic Shock Working Group Registry
RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT04682483From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.