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Heart Failure clinical trials recruiting in the U.S.
221 studies for Heart Failure are recruiting participants at sites across the United States.
Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.
Cities with the most studies
- New York City, NY50 studies
- Boston, MA43 studies
- Dallas, TX43 studies
- Houston, TX36 studies
- Cleveland, OH33 studies
- Chicago, IL32 studies
- Philadelphia, PA31 studies
- San Francisco, CA29 studies
- St. Louis, MO26 studies
- Durham, NC26 studies
- Atlanta, GA25 studies
- Kansas City, MO25 studies
- Cincinnati, OH24 studies
- Baltimore, MD24 studies
- Indianapolis, IN23 studies
- San Diego, CA23 studies
- Rochester, MN22 studies
- Ann Arbor, MI22 studies
- Minneapolis, MN21 studies
- Jacksonville, FL21 studies
- Los Angeles, CA20 studies
- Nashville, TN19 studies
- Pittsburgh, PA19 studies
- Washington, DC19 studies
- Austin, TX18 studies
- Charleston, SC18 studies
- Tampa, FL18 studies
- Aurora, CO18 studies
- Phoenix, AZ18 studies
- Seattle, WA17 studies
- Salt Lake City, UT17 studies
- Portland, OR17 studies
- Orlando, FL16 studies
- Milwaukee, WI16 studies
- Richmond, VA16 studies
- Columbus, OH15 studies
- Arlington, VA15 studies
- Mountain View, CA14 studies
- Harrisburg, PA14 studies
- Miami, FL14 studies
By state
- Alabama23 studies
- Arizona31 studies
- Arkansas11 studies
- California65 studies
- Colorado23 studies
- Connecticut21 studies
- Delaware3 studies
- District of Columbia12 studies
- Florida50 studies
- Georgia28 studies
- Idaho5 studies
- Illinois44 studies
- Indiana29 studies
- Iowa10 studies
- Kansas19 studies
- Kentucky21 studies
- Louisiana20 studies
- Maine6 studies
- Maryland28 studies
- Massachusetts44 studies
- Michigan37 studies
- Minnesota43 studies
- Mississippi7 studies
- Missouri40 studies
- Nebraska21 studies
- Nevada7 studies
- New Jersey27 studies
- New Mexico4 studies
- New York56 studies
- North Carolina42 studies
- Ohio54 studies
- Oklahoma16 studies
- Oregon17 studies
- Pennsylvania45 studies
- Rhode Island4 studies
- South Carolina30 studies
- South Dakota15 studies
- Tennessee33 studies
- Texas68 studies
- Utah22 studies
- Vermont8 studies
- Virginia37 studies
- Washington26 studies
- West Virginia8 studies
- Wisconsin20 studies
Recently updated studies
A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07761117BiVACOR® Total Artificial Heart Early Feasibility Study
Recruiting
Ages 18 to 70 · All sexes · Updated Sep 28, 2026 · NCT06174103: Vascular Function in Health and Disease
RecruitingPhase 1Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT02966665Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Sep 24, 2026 · NCT06736574Barostim-Enabled NEurohormonal Intervention For Improving Treatment of Heart Failure
Recruiting
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07232030Evaluation of Liver Stiffness Performance, by FibroScan®, to Detect Elevated Central Venous Pressure (CVP)
Recruiting
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07222813A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06424288A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06935370A Study of LY3971297 in Participants With Heart Failure
RecruitingPhase 1
Ages 18 to 65 · All sexes · Updated Sep 22, 2026 · NCT07547540Tezspire Cardiac Events PASS
RecruitingObservational study
Ages 12 to 130 · All sexes · Updated Sep 18, 2026 · NCT06951867Cholate Clearance in Fontan and Heart Failure
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07009132Alleviant ALLAY-HFrEF Study
Recruiting
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06812533Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
RecruitingPhase 3
Ages 18 to 99 · All sexes · Updated Sep 16, 2026 · NCT07037459Technical Development of Cardiovascular Magnetic Resonance Imaging
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Sep 15, 2026 · NCT04927429Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
RecruitingPhase 3
Ages 40 and older · All sexes · Updated Sep 15, 2026 · NCT06677060Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
RecruitingPhase 3
Ages 18 to 130 · All sexes · Updated Sep 11, 2026 · NCT06307652A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06008197A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06024746The WiSE®-UP Study (The WiSE System Utilization & Performance Study)
RecruitingObservational study
Ages 22 and older · All sexes · Updated Sep 10, 2026 · NCT07098858Novel Technologies to Improve Echocardiographic Estimates of Left Ventricular Filling Pressure in Heart Failure Combined With Atrial Fibrillation
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07436299A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction
RecruitingPhase 1
Ages 18 to 100 · All sexes · Updated Sep 10, 2026 · NCT07465653Pedal Pump Clinical Trial on Edema V2
Recruiting
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07809516Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
Recruiting
Ages 18 to 100 · All sexes · Updated Sep 9, 2026 · NCT06310031Mechanisms of Diuretic Resistance in Heart Failure, Aim 2
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT05753059Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging
RecruitingObservational studyHealthy volunteers welcome
Ages 7 to 100 · All sexes · Updated Sep 8, 2026 · NCT03581318From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.