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Genes and Environment in Multiple Sclerosis
Integrating Genetic and Environmental Risk Scores Into an Algorithm to Predict Multiple Sclerosis Susceptibility
Who can join
Ages 18 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * First Degree Relatives of Patients with MS, or * Patients who have received anti-TNFa therapy as treatment for inflammatory diseases other than MS such as Crohn's disease, psoriasis and rheumatoid arthritis, or * Patients that have been referred for an evaluation of first presentation of neurologic symptoms but do not have a diagnosis of MS * Live in the United States Exclusion Criteria: * Does not match any of the inclusion criteria
About the study
The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS). While MS is not a disease caused by a single variation in genetic material (DNA), a single environmental factor, or a single malfunction in immune cells, there are genetic alterations, environmental exposures and immunologic factors that make the development of MS more likely. Obtaining information about who is at risk for MS will be beneficial in the future if the investigators can identify effective ways to prevent or slow down the progression of this disease.
Sponsor: Columbia University · Participants: 5,000 · Started: Oct 1, 2017
Contact the study team
- Juliana Oyegunle · Phone: 212-305-2434
Official record on ClinicalTrials.gov — NCT01353547
Locations in the U.S.
| Maryland | National Institute of Neurological Disorders and Stroke, Bethesda |
| New York | Columbia University Irving Center, New York |
| Pennsylvania | University of Pittsburgh, Pittsburgh |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.