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Multiple Sclerosis clinical trials recruiting in the U.S.
132 studies for Multiple Sclerosis are recruiting participants at sites across the United States.
Multiple sclerosis (MS) slows down or blocks messages between the brain and body. MS can be mild or severe. Learn about MS symptoms and treatment.
Cities with the most studies
- New York City, NY17 studies
- Chicago, IL15 studies
- Boston, MA14 studies
- Washington, DC13 studies
- Cleveland, OH10 studies
- Birmingham, AL9 studies
- Aurora, CO8 studies
- Kansas City, KS8 studies
- St. Louis, MO8 studies
- San Francisco, CA8 studies
- Tampa, FL7 studies
- Dallas, TX7 studies
- Columbus, OH7 studies
- Atlanta, GA7 studies
- Milwaukee, WI7 studies
- Baltimore, MD7 studies
- Seattle, WA7 studies
- Farmington Hills, MI6 studies
- Houston, TX6 studies
- Naples, FL5 studies
- Austin, TX5 studies
- Brockton, MA5 studies
- San Diego, CA5 studies
- Raleigh, NC4 studies
- Ann Arbor, MI4 studies
- Gainesville, FL4 studies
- Orlando, FL4 studies
- Scottsdale, AZ4 studies
- Champaign, IL4 studies
- Miami, FL4 studies
- Knoxville, TN4 studies
- Philadelphia, PA4 studies
- Mountain View, CA4 studies
- New Haven, CT4 studies
- Durham, NC4 studies
- Oklahoma City, OK3 studies
- Kirkland, WA3 studies
- Fort Collins, CO3 studies
- Honolulu, HI3 studies
- Sandy Springs, GA3 studies
By state
- Alabama9 studies
- Arizona6 studies
- California24 studies
- Colorado12 studies
- Connecticut6 studies
- District of Columbia4 studies
- Florida16 studies
- Georgia8 studies
- Hawaii3 studies
- Illinois19 studies
- Kansas9 studies
- Kentucky3 studies
- Maryland17 studies
- Massachusetts19 studies
- Michigan10 studies
- Minnesota4 studies
- Missouri8 studies
- Nebraska3 studies
- New Jersey11 studies
- New York20 studies
- North Carolina9 studies
- Ohio15 studies
- Oklahoma4 studies
- Pennsylvania8 studies
- Tennessee6 studies
- Texas18 studies
- Utah3 studies
- Virginia3 studies
- Washington10 studies
- Wisconsin8 studies
Recently updated studies
Skeletal Muscle Aging and Responsiveness in Aged People With MS
Recruiting
Ages 60 and older · All sexes · Updated Nov 12, 2026 · NCT07500727Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT03816345Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System
RecruitingObservational studyHealthy volunteers welcome
1 Month – 99 Years · All sexes · Updated Nov 12, 2026 · NCT00794352Investigating the Impact of Treadmill-integrated Virtual Reality Training on Walking Outside the Clinic
Recruiting
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07927439Targeting Agonists of Glucagon-like Peptide-1 Receptor for Multiple Sclerosis
RecruitingPhase 2
Ages 18 to 60 · All sexes · Updated Nov 10, 2026 · NCT07497399RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Nov 10, 2026 · NCT07002034Kesimpta (Ofatumumab) Pregnancy Registry
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Nov 10, 2026 · NCT05634967Metformin as an add-on or Monotherapy in Treatment of Aging People With Multiple Sclerosis (MS)
RecruitingPhase 2
Ages 55 to 75 · All sexes · Updated Nov 6, 2026 · NCT06463743Dalfampridine Combined With Physical Therapy for Mobility Impairment in Multiple Sclerosis
RecruitingPhase 3
Ages 25 to 75 · All sexes · Updated Nov 6, 2026 · NCT06136728Wearable Focal Vibration Therapy on Upper Extremity Function of People With Multiple Sclerosis: A Pilot Study
Recruiting
Ages 18 to 100 · All sexes · Updated Nov 3, 2026 · NCT07376772HOBSCOTCH-MS-Efficacy Trial
Recruiting
Ages 20 to 75 · All sexes · Updated Nov 2, 2026 · NCT06951919Understanding and Enhancing Human Health and Movement
Recruiting
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT07738978A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressive and Primary Progressive Multiple Sclerosis (SPMS/PPMS)
RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Oct 30, 2026 · NCT07840326A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)
RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT06433752A Study of Ocrelizumab Administered Subcutaneously in Participants With Multiple Sclerosis Who Switch From an Approved Anti-CD20 Therapy
RecruitingPhase 4
Ages 18 to 65 · All sexes · Updated Oct 30, 2026 · NCT07609719Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)
RecruitingObservational studyHealthy volunteers welcome
Ages 2 to 120 · All sexes · Updated Oct 29, 2026 · NCT01730131Dry Needling in Multiple Sclerosis
Recruiting
Ages 18 to 80 · All sexes · Updated Oct 29, 2026 · NCT07615725A Study Evaluating the Effect of BRIUMVI® (Ublituximab) on Pregnancy and Infant Outcomes in Participants With Multiple Sclerosis (MS)
RecruitingObservational study
Ages 15 to 50 · Women · Updated Oct 29, 2026 · NCT06433765Efgartigimod for the Treatment of Acute Optic Neuritis
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT06453694A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity
RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Oct 27, 2026 · NCT06782490A Study to Assess the Safety and Clinical Activity of Azer-cel in Participants With B-cell Mediated Autoimmune Disorders
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT06680037iConquerMS™ - A Patient-Powered Research Network for Multiple Sclerosis
RecruitingObservational studyHealthy volunteers welcome
All ages · All sexes · Updated Oct 27, 2026 · NCT02486562Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 120 · All sexes · Updated Oct 26, 2026 · NCT00001248Care in Multiple Sclerosis (MS)
RecruitingObservational study
Ages 18 to 29 · All sexes · Updated Oct 26, 2026 · NCT07011914Incremental Vestibulo-ocular Reflex Adaptation as a Novel Treatment for Dizziness in People With Multiple Sclerosis
RecruitingHealthy volunteers welcome
Ages 18 to 89 · All sexes · Updated Oct 23, 2026 · NCT06495138From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.