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Multiple Sclerosis clinical trials recruiting in the U.S.

132 studies for Multiple Sclerosis are recruiting participants at sites across the United States.

Multiple sclerosis (MS) slows down or blocks messages between the brain and body. MS can be mild or severe. Learn about MS symptoms and treatment.

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Recently updated studies

Skeletal Muscle Aging and Responsiveness in Aged People With MS

Recruiting
Ages 60 and older · All sexes · Updated Nov 12, 2026 · NCT07500727

Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT03816345

Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System

RecruitingObservational studyHealthy volunteers welcome
1 Month – 99 Years · All sexes · Updated Nov 12, 2026 · NCT00794352

Investigating the Impact of Treadmill-integrated Virtual Reality Training on Walking Outside the Clinic

Recruiting
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07927439

Targeting Agonists of Glucagon-like Peptide-1 Receptor for Multiple Sclerosis

RecruitingPhase 2
Ages 18 to 60 · All sexes · Updated Nov 10, 2026 · NCT07497399

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Nov 10, 2026 · NCT07002034

Kesimpta (Ofatumumab) Pregnancy Registry

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Nov 10, 2026 · NCT05634967

Metformin as an add-on or Monotherapy in Treatment of Aging People With Multiple Sclerosis (MS)

RecruitingPhase 2
Ages 55 to 75 · All sexes · Updated Nov 6, 2026 · NCT06463743

Dalfampridine Combined With Physical Therapy for Mobility Impairment in Multiple Sclerosis

RecruitingPhase 3
Ages 25 to 75 · All sexes · Updated Nov 6, 2026 · NCT06136728

Wearable Focal Vibration Therapy on Upper Extremity Function of People With Multiple Sclerosis: A Pilot Study

Recruiting
Ages 18 to 100 · All sexes · Updated Nov 3, 2026 · NCT07376772

HOBSCOTCH-MS-Efficacy Trial

Recruiting
Ages 20 to 75 · All sexes · Updated Nov 2, 2026 · NCT06951919

Understanding and Enhancing Human Health and Movement

Recruiting
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT07738978

A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)

RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT06433752

Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)

RecruitingObservational studyHealthy volunteers welcome
Ages 2 to 120 · All sexes · Updated Oct 29, 2026 · NCT01730131

Dry Needling in Multiple Sclerosis

Recruiting
Ages 18 to 80 · All sexes · Updated Oct 29, 2026 · NCT07615725

A Study Evaluating the Effect of BRIUMVI® (Ublituximab) on Pregnancy and Infant Outcomes in Participants With Multiple Sclerosis (MS)

RecruitingObservational study
Ages 15 to 50 · Women · Updated Oct 29, 2026 · NCT06433765

Efgartigimod for the Treatment of Acute Optic Neuritis

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT06453694

A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity

RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Oct 27, 2026 · NCT06782490

A Study to Assess the Safety and Clinical Activity of Azer-cel in Participants With B-cell Mediated Autoimmune Disorders

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT06680037

iConquerMS™ - A Patient-Powered Research Network for Multiple Sclerosis

RecruitingObservational studyHealthy volunteers welcome
All ages · All sexes · Updated Oct 27, 2026 · NCT02486562

Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 120 · All sexes · Updated Oct 26, 2026 · NCT00001248

Care in Multiple Sclerosis (MS)

RecruitingObservational study
Ages 18 to 29 · All sexes · Updated Oct 26, 2026 · NCT07011914

Incremental Vestibulo-ocular Reflex Adaptation as a Novel Treatment for Dizziness in People With Multiple Sclerosis

RecruitingHealthy volunteers welcome
Ages 18 to 89 · All sexes · Updated Oct 23, 2026 · NCT06495138

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.