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Multiple Sclerosis clinical trials recruiting in the U.S.

132 studies for Multiple Sclerosis are recruiting participants at sites across the United States.

Multiple sclerosis (MS) slows down or blocks messages between the brain and body. MS can be mild or severe. Learn about MS symptoms and treatment.

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Recently updated studies

Vancomycin Study in Multiple Sclerosis (MS)

RecruitingPhase 1
Ages 18 to 50 · All sexes · Updated Sep 28, 2026 · NCT05539729

Understanding the Impact of Meal Timing on Neurological Health in Adults With Multiple Sclerosis

Recruiting
Ages 18 to 64 · All sexes · Updated Sep 25, 2026 · NCT07475377

A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT06433752

Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT03816345

Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System

RecruitingObservational studyHealthy volunteers welcome
1 Month – 99 Years · All sexes · Updated Sep 22, 2026 · NCT00794352

Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis

RecruitingPhase 1/2
Ages 18 to 65 · All sexes · Updated Sep 21, 2026 · NCT07477639

A Study Evaluating the Effect of BRIUMVI® (Ublituximab) on Pregnancy and Infant Outcomes in Participants With Multiple Sclerosis (MS)

RecruitingObservational study
Ages 15 to 50 · Women · Updated Sep 21, 2026 · NCT06433765

Delivery of a Culturally Tailored Exercise Training Intervention for Hispanics With Multiple Sclerosis

Recruiting
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07606742

Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 120 · All sexes · Updated Sep 16, 2026 · NCT00001248

Clinical Applications of Advanced Ophthalmic Imaging

RecruitingHealthy volunteers welcome
Ages 18 to 99 · All sexes · Updated Sep 16, 2026 · NCT03135327

Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques

RecruitingPhase 2
Ages 18 to 120 · All sexes · Updated Sep 16, 2026 · NCT02784210

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Sep 15, 2026 · NCT07002034

Exploring the Utility of [18F]3F4AP for Demyelination Imaging

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 90 · All sexes · Updated Sep 9, 2026 · NCT06999434

A Study to Assess the Safety and Clinical Activity of Azer-cel in Participants With B-cell Mediated Autoimmune Disorders

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06680037

Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)

RecruitingObservational studyHealthy volunteers welcome
Ages 2 to 120 · All sexes · Updated Aug 31, 2026 · NCT01730131

Identifying and Characterizing Preclinical MS

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT05787795

Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)

RecruitingPhase 1/2
Ages 18 to 120 · All sexes · Updated Aug 27, 2026 · NCT03109288

An Open-label Study of AZD0120 in Adults With Multiple Sclerosis

RecruitingPhase 1
Ages 18 to 60 · All sexes · Updated Aug 25, 2026 · NCT07224373

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.