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Multiple Sclerosis clinical trials recruiting in the U.S.
132 studies for Multiple Sclerosis are recruiting participants at sites across the United States.
Multiple sclerosis (MS) slows down or blocks messages between the brain and body. MS can be mild or severe. Learn about MS symptoms and treatment.
Cities with the most studies
- New York City, NY17 studies
- Chicago, IL15 studies
- Boston, MA14 studies
- Washington, DC13 studies
- Cleveland, OH9 studies
- St. Louis, MO8 studies
- Kansas City, KS8 studies
- Birmingham, AL8 studies
- San Francisco, CA8 studies
- Seattle, WA7 studies
- Columbus, OH7 studies
- Baltimore, MD7 studies
- Aurora, CO7 studies
- Farmington Hills, MI6 studies
- Milwaukee, WI6 studies
- Houston, TX6 studies
- Dallas, TX6 studies
- San Diego, CA5 studies
- Tampa, FL5 studies
- Austin, TX5 studies
- Atlanta, GA5 studies
- Durham, NC4 studies
- Brockton, MA4 studies
- New Haven, CT4 studies
- Naples, FL4 studies
- Knoxville, TN4 studies
- Champaign, IL4 studies
- Miami, FL4 studies
- Ann Arbor, MI4 studies
- Cincinnati, OH3 studies
- Rochester, MN3 studies
- Buffalo, NY3 studies
- Philadelphia, PA3 studies
- Mountain View, CA3 studies
- Kirkland, WA3 studies
- Scottsdale, AZ3 studies
- Plano, TX3 studies
- Burbank, CA3 studies
- Phoenix, AZ3 studies
- Palm Coast, FL3 studies
By state
- Alabama8 studies
- Arizona5 studies
- California24 studies
- Colorado11 studies
- Connecticut6 studies
- District of Columbia4 studies
- Florida13 studies
- Georgia7 studies
- Hawaii3 studies
- Illinois19 studies
- Kansas9 studies
- Kentucky3 studies
- Maryland17 studies
- Massachusetts18 studies
- Michigan10 studies
- Minnesota4 studies
- Missouri8 studies
- Nebraska3 studies
- New Jersey11 studies
- New York19 studies
- North Carolina8 studies
- Ohio14 studies
- Oklahoma3 studies
- Pennsylvania7 studies
- Tennessee6 studies
- Texas17 studies
- Utah3 studies
- Virginia3 studies
- Washington11 studies
- Wisconsin7 studies
Recently updated studies
Vancomycin Study in Multiple Sclerosis (MS)
RecruitingPhase 1
Ages 18 to 50 · All sexes · Updated Sep 28, 2026 · NCT05539729Understanding the Impact of Meal Timing on Neurological Health in Adults With Multiple Sclerosis
Recruiting
Ages 18 to 64 · All sexes · Updated Sep 25, 2026 · NCT07475377A Phase 2a Study of SUN-627 in Participants With Non-Active Secondary Progressive and Primary Progressive Multiple Sclerosis (SPMS/PPMS)
RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Sep 25, 2026 · NCT07840326A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT06433752Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT03816345Comprehensive Multimodal Analysis of Neuroimmunological Diseases of the Central Nervous System
RecruitingObservational studyHealthy volunteers welcome
1 Month – 99 Years · All sexes · Updated Sep 22, 2026 · NCT00794352Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis
RecruitingPhase 1/2
Ages 18 to 65 · All sexes · Updated Sep 21, 2026 · NCT07477639A Study Evaluating the Effect of BRIUMVI® (Ublituximab) on Pregnancy and Infant Outcomes in Participants With Multiple Sclerosis (MS)
RecruitingObservational study
Ages 15 to 50 · Women · Updated Sep 21, 2026 · NCT06433765Delivery of a Culturally Tailored Exercise Training Intervention for Hispanics With Multiple Sclerosis
Recruiting
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07606742Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 120 · All sexes · Updated Sep 16, 2026 · NCT00001248Clinical Applications of Advanced Ophthalmic Imaging
RecruitingHealthy volunteers welcome
Ages 18 to 99 · All sexes · Updated Sep 16, 2026 · NCT03135327Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques
RecruitingPhase 2
Ages 18 to 120 · All sexes · Updated Sep 16, 2026 · NCT02784210Treatment of Cognitive Deficits in Multiple Sclerosis With High-Definition Transcranial Direct Current Stimulation
Recruiting
Ages 18 to 65 · All sexes · Updated Sep 15, 2026 · NCT05958381Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis
RecruitingPhase 3
Ages 18 to 60 · All sexes · Updated Sep 15, 2026 · NCT07325292RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Sep 15, 2026 · NCT07002034Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis
RecruitingPhase 3
Ages 10 to 17 · All sexes · Updated Sep 10, 2026 · NCT06408259A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity
RecruitingPhase 2
Ages 18 to 70 · All sexes · Updated Sep 9, 2026 · NCT06782490Exploring the Utility of [18F]3F4AP for Demyelination Imaging
RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 90 · All sexes · Updated Sep 9, 2026 · NCT06999434A Study to Assess the Safety and Clinical Activity of Azer-cel in Participants With B-cell Mediated Autoimmune Disorders
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06680037A Study of Ocrelizumab Administered Subcutaneously in Participants With Multiple Sclerosis Who Switch From an Approved Anti-CD20 Therapy
RecruitingPhase 4
Ages 18 to 65 · All sexes · Updated Sep 8, 2026 · NCT07609719Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)
RecruitingObservational studyHealthy volunteers welcome
Ages 2 to 120 · All sexes · Updated Aug 31, 2026 · NCT01730131Evaluation of the Safety and Efficacy of a Full-Body Electrostimulation Garment for Individuals With Neurological and Neuromuscular Conditions That Cause Spasticity, Hyperreflexia, and Pain
Recruiting
Ages 18 to 75 · All sexes · Updated Aug 28, 2026 · NCT07132775Identifying and Characterizing Preclinical MS
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT05787795Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)
RecruitingPhase 1/2
Ages 18 to 120 · All sexes · Updated Aug 27, 2026 · NCT03109288An Open-label Study of AZD0120 in Adults With Multiple Sclerosis
RecruitingPhase 1
Ages 18 to 60 · All sexes · Updated Aug 25, 2026 · NCT07224373From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.