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Assessment of Eloquent Function in Brain Tumor Patients
Assessment of Reorganization and Plasticity of Eloquent Function in Patients With Brain Tumors
Who can join
Ages 19 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * 19 years and older * Brain tumor in or near eloquent brain regions that is appropriate for attempted resection * Appropriate body habitus and mental status/capacity to participate with non-invasive or invasive mapping * Benign or malignant intra-axial brain tumor * Primary or metastatic intra-axial brain tumor Exclusion Criteria: * Any contraindication to MRI (i.e. implanted devices) * Inappropriate body habitus or mental status/capacity to participate with non-invasive or invasive mapping in a safe and reliable manner * Declining to participate * Lacks capacity to understand the study or consent for themselves * Neurologic status which precludes testing (poor function- not testable) * Positive pregnancy test * End stage renal disease or severe renal dysfunction
About the study
Purpose of the study:
AIM 1: Prospectively collect pre-operative \[functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), magnetoencephalography (MEG)\] and intra-operative mapping data in patients with intra-axial brain tumors to assess how well each modality predicts the location of eloquent brain function. In addition, each modality will be compared with the other.
AIM 2: Assess reorganization of eloquent brain function and plasticity in patients with intra-axial brain tumors. This will be accomplished by prospectively collecting post-operative mapping studies and neuropsychological tests to compare them to prior mapping studies as stated above.
What is being tested
- Brain mapping (diagnostic test)
Sponsor: University of Nebraska · Participants: 75 · Started: Jan 31, 2012
Contact the study team
- Dulce Maroni, PhD · Phone: 402-836-9751
- Katie Maire, MS · Phone: 402-559-6895
Official record on ClinicalTrials.gov — NCT01535430
Locations in the U.S.
| Nebraska | University of Nebraska Medical Center, Omaha |
Conditions
From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.