GI Neuromuscular Pathology Prospective Registry

RecruitingObservational studyHealthy volunteers welcome

Indiana University GI Neuromuscular Pathology Prospective Registry

Who can join

6 Months – 90 Years · All sexes · Healthy volunteers welcome

Full eligibility criteria

Inclusion Criteria Study Group:

Patients who are undergoing surgical full-thickness biopsy of the stomach and/or proximal jejunum for the clinical evaluation of GI neuromuscular disorder.

Inclusion Criteria Control Group:

Patients undergoing esophagectomy, sleeve gastrectomy for obesity, or Roux-en Y gastric bypass Patients undergoing Whipple surgery Patients undergoing transplant surgery

Patients who are organ donors and undergoing surgery

Exclusion Criteria Study Group:

Contraindication for surgical full-thickness biopsy for any reason. Significant comorbidity due to severe cardiovascular, renal, pulmonary, or liver disease.

Significant coagulopathy Non-ambulatory patients: bed-ridden, nursing home resident. Pregnant Unable to give own informed consent Prisoners

Exclusion Criteria Control Group:

Prior diagnosis of gastroparesis Prior diagnosis of chronic intestinal pseudo-obstruction Unable to give own informed consent if not an organ donor

About the study

In this research study, biopsy samples will be collected to provide more insight into the underlying cause of the motility disorders, help direct further investigation into the cause of the underlying condition, provide future prognosis and predict response to gastric electrical stimulation (GES).

What is being tested

Surgical Full Thickness Biopsy (procedure)

Sponsor: Indiana University · Participants: 300 · Started: Dec 1, 2013

Contact the study team

Official record on ClinicalTrials.gov — NCT02165059

Locations in the U.S.

Indiana

Indiana University Hosptial, Indianapolis

Conditions

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.