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GERD clinical trials recruiting in the U.S.

36 studies for GERD are recruiting participants at sites across the United States.

Gastroesophageal reflux disease (GERD) is a chronic condition that can cause discomfort and lead to other health problems. Its most common symptom is heartburn.

Cities with the most studies

By state

Recently updated studies

Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

RecruitingHealthy volunteers welcome
Ages 50 and older · All sexes · Updated Sep 15, 2026 · NCT06687603

Abbott Cephea Mitral Valve Disease Registry

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07069673

Gastrointestinal Dysmotility on Aspiration Risk

RecruitingPhase 4
Ages 5 to 21 · All sexes · Updated Aug 3, 2026 · NCT05455359

Utility of Mucosal Impedance Device in Chronic Esophageal Disorders:

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jul 27, 2026 · NCT07227506

Transventricular Off-pump Mitral Valve Repair

Recruiting
Ages 21 and older · All sexes · Updated Jul 24, 2026 · NCT07726173

Transpyloric Versus Gastric Feeding in Bronchopulmonary Dysplasia

Recruiting
1 Month – 12 Months · All sexes · Updated Jul 17, 2026 · NCT06534359

Mechanistic and Clinical Outcomes of a Surgical Innovation Aimed at Minimizing GERD Associated With VSG (INNOVATE-VSG)

Recruiting
Ages 18 to 65 · All sexes · Updated Jul 14, 2026 · NCT06783751

Randomized Controlled Crossover Trial of Postpyloric Feedings to Improve Pulmonary Outcomes in High-risk Preterm Infants

Recruiting
0 Hours – 1 Year · All sexes · Updated Jun 29, 2026 · NCT05777512

Safety and Effectiveness of eGERD Device to Reduce Gastroesophageal Reflux Disease (GERD) Symptoms

Recruiting
Ages 22 to 75 · All sexes · Updated Jun 23, 2026 · NCT06613438

GI Neuromuscular Pathology Prospective Registry

RecruitingObservational studyHealthy volunteers welcome
6 Months – 90 Years · All sexes · Updated Jun 16, 2026 · NCT02165059

Indiana University Gastrointestinal Motility Diagnosis Registry

RecruitingObservational study
All ages · All sexes · Updated Jun 16, 2026 · NCT04506593

Famotidine and Antacids for Treatment of Dyspepsia

RecruitingPhase 4
Ages 18 and older · All sexes · Updated Jun 2, 2026 · NCT06241183

Esophageal and Gastric Registry and Biorepository

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 85 · All sexes · Updated May 4, 2026 · NCT05180253

Endoscopic Bariatric Therapies (EBTs): A Retrospective and Prospective Multicenter Registry

RecruitingObservational study
Ages 18 to 89 · All sexes · Updated Apr 23, 2026 · NCT04494048

Esophageal Cancer Risk Registry

RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 14, 2026 · NCT00260585

Compassionate Use of Domperidone for Refractory Gastroparesis

Recruiting
Ages 12 to 21 · All sexes · Updated Mar 24, 2026 · NCT04699591

Clinical Utility of WATS3D: A 5-Year Prospective Study

RecruitingObservational study
Ages 18 and older · All sexes · Updated Mar 20, 2026 · NCT04312633

Implementing Virtual Reality (VR) to Reduce Sedation

RecruitingHealthy volunteers welcome
Ages 21 to 65 · All sexes · Updated Mar 19, 2026 · NCT06349564

External UES Band (Shaker Pressure Band) and GERD

Recruiting
Ages 18 to 85 · All sexes · Updated Mar 9, 2026 · NCT05697393

Post-sleeve Gastrectomy Gastroesophageal Reflux Disease Prediction

Recruiting
Ages 18 and older · All sexes · Updated Mar 5, 2026 · NCT04411823

Anti-Reflux Endoscopic TX Using APC (AREA) in GERD Patients: (The AREA Study)

Recruiting
Ages 18 to 80 · All sexes · Updated Feb 27, 2026 · NCT05570448

A Study of Breath Testing for Small Intestinal Bacterial Overgrowth

Recruiting
Ages 18 and older · All sexes · Updated Feb 12, 2026 · NCT05976165

Mechanisms Preventing Pharyngeal Reflux

RecruitingHealthy volunteers welcome
Ages 18 to 85 · All sexes · Updated Feb 10, 2026 · NCT05696184

Efficacy Of Hiatal Closure For GERD

RecruitingObservational study
Ages 18 to 50 · All sexes · Updated Feb 2, 2026 · NCT06280664

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.