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GERD clinical trials recruiting in the U.S.

37 studies for GERD are recruiting participants at sites across the United States.

Gastroesophageal reflux disease (GERD) is a chronic condition that can cause discomfort and lead to other health problems. Its most common symptom is heartburn.

Cities with the most studies

By state

Recently updated studies

TransCatheter Replacement Of the Mitral Valve With the Novel Cephea Mitral Valve System

Recruiting
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT07798726

Mesh Vs Pledgets for Repair of Paraesophageal Hernia

Recruiting
Ages 18 and older · All sexes · Updated Oct 26, 2026 · NCT05974722

Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

RecruitingHealthy volunteers welcome
Ages 50 and older · All sexes · Updated Sep 15, 2026 · NCT06687603

Abbott Cephea Mitral Valve Disease Registry

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07069673

Gastrointestinal Dysmotility on Aspiration Risk

RecruitingPhase 4
Ages 5 to 21 · All sexes · Updated Aug 3, 2026 · NCT05455359

Utility of Mucosal Impedance Device in Chronic Esophageal Disorders:

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jul 27, 2026 · NCT07227506

Transventricular Off-pump Mitral Valve Repair

Recruiting
Ages 21 and older · All sexes · Updated Jul 24, 2026 · NCT07726173

Transpyloric Versus Gastric Feeding in Bronchopulmonary Dysplasia

Recruiting
1 Month – 12 Months · All sexes · Updated Jul 17, 2026 · NCT06534359

Mechanistic and Clinical Outcomes of a Surgical Innovation Aimed at Minimizing GERD Associated With VSG (INNOVATE-VSG)

Recruiting
Ages 18 to 65 · All sexes · Updated Jul 14, 2026 · NCT06783751

Randomized Controlled Crossover Trial of Postpyloric Feedings to Improve Pulmonary Outcomes in High-risk Preterm Infants

Recruiting
0 Hours – 1 Year · All sexes · Updated Jun 29, 2026 · NCT05777512

Safety and Effectiveness of eGERD Device to Reduce Gastroesophageal Reflux Disease (GERD) Symptoms

Recruiting
Ages 22 to 75 · All sexes · Updated Jun 23, 2026 · NCT06613438

GI Neuromuscular Pathology Prospective Registry

RecruitingObservational studyHealthy volunteers welcome
6 Months – 90 Years · All sexes · Updated Jun 16, 2026 · NCT02165059

Indiana University Gastrointestinal Motility Diagnosis Registry

RecruitingObservational study
All ages · All sexes · Updated Jun 16, 2026 · NCT04506593

Famotidine and Antacids for Treatment of Dyspepsia

RecruitingPhase 4
Ages 18 and older · All sexes · Updated Jun 2, 2026 · NCT06241183

Esophageal and Gastric Registry and Biorepository

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 85 · All sexes · Updated May 4, 2026 · NCT05180253

Endoscopic Bariatric Therapies (EBTs): A Retrospective and Prospective Multicenter Registry

RecruitingObservational study
Ages 18 to 89 · All sexes · Updated Apr 23, 2026 · NCT04494048

Esophageal Cancer Risk Registry

RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 14, 2026 · NCT00260585

Compassionate Use of Domperidone for Refractory Gastroparesis

Recruiting
Ages 12 to 21 · All sexes · Updated Mar 24, 2026 · NCT04699591

Clinical Utility of WATS3D: A 5-Year Prospective Study

RecruitingObservational study
Ages 18 and older · All sexes · Updated Mar 20, 2026 · NCT04312633

Implementing Virtual Reality (VR) to Reduce Sedation

RecruitingHealthy volunteers welcome
Ages 21 to 65 · All sexes · Updated Mar 19, 2026 · NCT06349564

External UES Band (Shaker Pressure Band) and GERD

Recruiting
Ages 18 to 85 · All sexes · Updated Mar 9, 2026 · NCT05697393

Post-sleeve Gastrectomy Gastroesophageal Reflux Disease Prediction

Recruiting
Ages 18 and older · All sexes · Updated Mar 5, 2026 · NCT04411823

Anti-Reflux Endoscopic TX Using APC (AREA) in GERD Patients: (The AREA Study)

Recruiting
Ages 18 to 80 · All sexes · Updated Feb 27, 2026 · NCT05570448

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.