Reversal of Lipid-Induced Insulin Resistance

Inclusion Criteria:

* Healthy, sedentary, non-smoking and not taking any medications other than birth control pills.
* Hematocrit \>35%
* Subjects will have no systemic or organ disease including diabetes.
* Subjects will have no history eating disorders.
* Women must be using a form of birth control (sexual abstinence, birth control pills, Norplant, IUD or condoms) and will be studied between day 0 and 7 of their menstrual cycle.
* Those who are taking birth control pills or have had a hysterectomy may be studied at any time.
* Physical activity will be assessed using a standard questionnaire with an activity index cut off at 2.3.

Exclusion Criteria:

* Any subject, who does not fit the inclusion criteria. Including history of eating disorders, any systemic and organ disease including diabetes.

Lactose intolerance Any blood count, clotting abnormalities HYpertriglyceridemeia (TG over 100 mg/dL)

* Hematocrit \<35%.
* Women of childbearing potential, who are not using contraception (as mentioned above) or who are not abstinent.
* Subjects who have a regular exercise regimen will not be enrolled.
* Metal implants and/or body piercing, which cannot be removed before the MR studies.