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Steatotic Liver Disease clinical trials recruiting in the U.S.

61 studies for Steatotic Liver Disease are recruiting participants at sites across the United States.

Steatotic liver disease, formerly called fatty liver disease, happens when too much fat builds up in your liver. Learn about the causes and treatments.

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Recently updated studies

A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH

RecruitingPhase 3
Ages 18 to 80 · All sexes · Updated Nov 12, 2026 · NCT06528314

Study to Evaluate ALN-CIDEB in Adults With Fibrotic Metabolic Dysfunction-Associated Steatohepatitis (MASH)

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Nov 9, 2026 · NCT07631637

NAFLD Clinical Care Pathway

RecruitingHealthy volunteers welcome
Ages 18 to 80 · All sexes · Updated Nov 9, 2026 · NCT06671886

Trial to Evaluate ALN-CIDEB in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Nov 5, 2026 · NCT07854782

A Study of Efimosfermin Alfa in Participants With Biopsy-confirmed Cirrhosis (Compensated) Due to MASH

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Nov 5, 2026 · NCT06920043

A Study of Efimosfermin Alfa in Adults With Hepatic Impairment

RecruitingPhase 1
Ages 18 to 70 · All sexes · Updated Nov 5, 2026 · NCT07358546

Early Tracking of Childhood Health Determinants (ETCHED) Study

RecruitingObservational studyHealthy volunteers welcome
1 Day – 99 Years · All sexes · Updated Nov 2, 2026 · NCT03481829

Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)

RecruitingPhase 2Healthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Oct 27, 2026 · NCT03884075

Evaluation of Non-Invasive Tests for Metabolic Liver Disease

RecruitingObservational study
Ages 18 to 75 · All sexes · Updated Oct 26, 2026 · NCT07122700

A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH

RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Oct 23, 2026 · NCT06419374

A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)

RecruitingPhase 3
Ages 18 to 80 · All sexes · Updated Oct 23, 2026 · NCT06318169

Blood Collection Biorepository for Liver Disease Research

RecruitingObservational studyHealthy volunteers welcome
Ages 7 and older · All sexes · Updated Oct 8, 2026 · NCT03025074

A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 8, 2026 · NCT07165028

A Phase 2a Study of ALN-PNP With and Without a GLP1R Agonist in Adult Patients With Homozygous PNPLA3-Related MASLD

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 29, 2026 · NCT07527910

Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 28, 2026 · NCT05832229

Impact of Soymilk on Liver Disease Severity of Children With Non-alcoholic Fatty Liver Disease (NAFLD)

RecruitingPhase 2
Ages 5 to 16 · All sexes · Updated Sep 22, 2026 · NCT06133101

Human Models of Selective Insulin Resistance: Alpelisib, Part I

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 70 · All sexes · Updated Aug 24, 2026 · NCT06354088

InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer

RecruitingObservational studyHealthy volunteers welcome
All ages · All sexes · Updated Aug 17, 2026 · NCT05463796

Quantifying Hepatic Mitochondrial Fluxes in Humans

RecruitingPhase 4
Ages 18 to 80 · All sexes · Updated Aug 17, 2026 · NCT05305287

Acute Exercise and Endogenous Glucose Production in Type 2 Diabetes: Implications for Glycemic Control and Treatment of Hepatic Steatosis

RecruitingHealthy volunteers welcome
Ages 25 to 55 · All sexes · Updated Aug 12, 2026 · NCT06993454

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.