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Steatotic Liver Disease clinical trials recruiting in the U.S.

65 studies for Steatotic Liver Disease are recruiting participants at sites across the United States.

Steatotic liver disease, formerly called fatty liver disease, happens when too much fat builds up in your liver. Learn about the causes and treatments.

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Recently updated studies

Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 28, 2026 · NCT05832229

Early Tracking of Childhood Health Determinants (ETCHED) Study

RecruitingObservational studyHealthy volunteers welcome
1 Day – 99 Years · All sexes · Updated Sep 28, 2026 · NCT03481829

Impact of Soymilk on Liver Disease Severity of Children With Non-alcoholic Fatty Liver Disease (NAFLD)

RecruitingPhase 2
Ages 5 to 16 · All sexes · Updated Sep 22, 2026 · NCT06133101

A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07165028

A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH

RecruitingPhase 3
Ages 18 to 80 · All sexes · Updated Sep 21, 2026 · NCT06528314

Fully Automated High-Throughput Quantitative MRI of the Liver

RecruitingObservational studyHealthy volunteers welcome
Ages 7 and older · All sexes · Updated Sep 16, 2026 · NCT05294471

A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH

RecruitingPhase 3
Ages 18 to 75 · All sexes · Updated Sep 3, 2026 · NCT06419374

A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)

RecruitingPhase 3
Ages 18 to 80 · All sexes · Updated Sep 3, 2026 · NCT06318169

Human Models of Selective Insulin Resistance: Alpelisib, Part I

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 70 · All sexes · Updated Aug 24, 2026 · NCT06354088

Quantifying Hepatic Mitochondrial Fluxes in Humans

RecruitingPhase 4
Ages 18 to 80 · All sexes · Updated Aug 17, 2026 · NCT05305287

InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer

RecruitingObservational studyHealthy volunteers welcome
All ages · All sexes · Updated Aug 17, 2026 · NCT05463796

Acute Exercise and Endogenous Glucose Production in Type 2 Diabetes: Implications for Glycemic Control and Treatment of Hepatic Steatosis

RecruitingHealthy volunteers welcome
Ages 25 to 55 · All sexes · Updated Aug 12, 2026 · NCT06993454

A Phase 2a Study of ALN-PNP With and Without a GLP1R Agonist in Adult Patients With Homozygous PNPLA3-Related MASLD

RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Aug 10, 2026 · NCT07527910

Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)

RecruitingPhase 2Healthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Aug 10, 2026 · NCT03884075

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity

RecruitingHealthy volunteers welcome
Ages 18 to 70 · All sexes · Updated Aug 6, 2026 · NCT06335771

Effects of Peanut Consumption on Adults With Metabolic Associated Fatty Liver Disease

Recruiting
Ages 30 to 70 · All sexes · Updated Aug 6, 2026 · NCT07646197

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 70 · All sexes · Updated Aug 6, 2026 · NCT06571474

Fibrosis Lessens After Metabolic Surgery

RecruitingPhase 4Healthy volunteers welcome
Ages 18 to 75 · All sexes · Updated Jul 31, 2026 · NCT06374875

Pathogenesis of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD)

RecruitingObservational study
Ages 12 to 18 · All sexes · Updated Jul 30, 2026 · NCT04634643

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.