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Neuronal Effects of Exercise in Schizophrenia

Who can join

Ages 21 to 70 · All sexes

Inclusion Criteria:

* Diagnosis of schizophrenia or schizoaffective disorder
* Between 21 and 70 years of age
* Currently prescribed either olanzapine, risperidone, clozapine, or haloperidol, OR not currently being treated with any neuroleptic medications
* Weight stable within 5 percent for the last 6 months

Exclusion Criteria:

* Pregnancy
* Substance abuse
* Significant endocrine/metabolic disease (e.g., uncontrolled hypertension, severe hypertriglyceridemia)
* MRI-specific exclusion criteria (e.g., claustrophobia, metal in the body)

About the study

This study plans to learn more about how common drugs prescribed to individuals with schizophrenia contribute to weight gain, as well as how exercise and diet impact appetite and the brain's response to food. In this study, the investigators will be evaluating how participants' brains respond to food images as well as asking questions about their food preferences and intake and clinical symptoms. The investigators may also ask participants to complete an exercise or diet intervention to see how this changes brain responses or food preferences.

What is being tested

• Exercise (behavioral)
• Diet (behavioral)

Sponsor: University of Colorado, Denver · Participants: 140 · Started: 2014-08

Contact the study team

• Kristina T Legget, Ph.D. · Phone: 303-724-5809

Official record on ClinicalTrials.gov — NCT02455193

Locations in the U.S.

Conditions

• Schizophrenia

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.