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Schizophrenia clinical trials recruiting in the U.S.

105 studies for Schizophrenia are recruiting participants at sites across the United States.

Schizophrenia is a serious brain illness that can include hearing voices that aren't there and thinking others are trying to hurt them.

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Recently updated studies

Relapse Prevention Trial Evaluating KarXT Treatment in Schizophrenia

RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 28, 2026 · NCT07686263

Efficacy of NBI-1117568 in Preventing Relapse in Adults With Schizophrenia

RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 25, 2026 · NCT07227818

NBI-1117568-SCZ3032: Long-Term Evaluation of NBI-1117568 in Adults With Schizophrenia

RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 25, 2026 · NCT07114874

NBI-1117568-SCZ3030: Evaluation of NBI-1117568 in Inpatient Adults With Schizophrenia

RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 25, 2026 · NCT07105098

Study to Evaluate the Safety and Efficacy of Ublituximab in Participants With Schizophrenia

RecruitingPhase 2
Ages 18 to 60 · All sexes · Updated Sep 23, 2026 · NCT07680946

State Representation in Early Psychosis 2

RecruitingObservational studyHealthy volunteers welcome
Ages 15 to 45 · All sexes · Updated Sep 22, 2026 · NCT07834203

A Study of Brenipatide in Adult Participants With Schizophrenia

RecruitingPhase 2
Ages 18 to 55 · All sexes · Updated Sep 22, 2026 · NCT07410507

A Study of LTX-001 In Adult Participants With Acute Exacerbation of Schizophrenia

RecruitingPhase 1
Ages 18 to 55 · All sexes · Updated Sep 17, 2026 · NCT07734493

Circuitry-Guided Smoking Cessation in Schizophrenia (UH3)

Recruiting
Ages 22 to 65 · All sexes · Updated Sep 16, 2026 · NCT05276050

52-week Open Label Safety-Tolerability Study

RecruitingPhase 3
Ages 18 to 65 · All sexes · Updated Sep 9, 2026 · NCT07369154

A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Schizophrenia in Adolescents (EMERGENT TEEN)

RecruitingPhase 3
Ages 13 to 17 · All sexes · Updated Sep 4, 2026 · NCT07288567

Genetic Basis of the Risk and Consequences of Cannabis Exposure in Humans

RecruitingPhase 1Healthy volunteers welcome
Ages 21 to 60 · All sexes · Updated Sep 2, 2026 · NCT06058702

A Study to Evaluate the Safety, Tolerability, and PK of an Injectable Form of KarXT

RecruitingPhase 1
Ages 18 to 55 · All sexes · Updated Sep 2, 2026 · NCT07061288

A Long-Term Open-Label Study of ML-007C-MA in Adults With Schizophrenia

RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Sep 1, 2026 · NCT07459647

Overnight Thalamic TES-TI to Modulate Sleep Spindles in Individuals With Schizophrenia Spectrum Disorders and Matched Healthy Controls

RecruitingHealthy volunteers welcome
Ages 18 to 50 · All sexes · Updated Aug 31, 2026 · NCT07680114

Activities to Change Your Mood: A Test of the Acceptability and Initial Efficacy in Clinical Samples and Healthy Controls

RecruitingHealthy volunteers welcome
Ages 18 to 65 · All sexes · Updated Aug 31, 2026 · NCT06911723

Cerebellar Modulation of Cognition in Psychosis

Recruiting
Ages 18 to 55 · All sexes · Updated Aug 20, 2026 · NCT06107764

Evaluation of Treatment Satisfaction and KarXT Utilization Registry (RESKU)

RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT07101094

Enhancing Veteran-Clinical Collaboration in VA PRRCs

Recruiting
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT06898879

Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT)

RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT07379827

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.