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Investigations of Dementia in Parkinson Disease
Who can join
Ages 50 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * PD patients must exhibit three of the following cardinal signs: rest tremor, rigidity, bradykinesia, or postural instability; or two of these features with one of the first three displaying asymmetry. Exclusion Criteria: * history of head trauma, major neurological or psychiatric diseases other than Parkinson disease and dementia, e.g. stroke, multiple sclerosis, depression or schizophrenia. * severe systemic diseases. * inability to lie still for 90 minutes. * metallic implants, pacemakers, or any other contraindication to MRI. * refusal to consent to brain donation.
About the study
The purpose of this study is to use a brain imaging method called Pittsburgh B (PIB) Positron Emission Tomography (PET) and Vesicular Cholinergic Transport (VAT) PET to determine dementia subtypes in patients with Parkinson disease (PD). The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia.
What is being tested
- PiB and VAT (radiation)
Sponsor: Washington University School of Medicine · Participants: 320 · Started: 2016-06
Contact the study team
- Andrea Slavik, RN, BSN · Phone: 314 273 8313
- Hailee Domash · Phone: 314 362 6026
Official record on ClinicalTrials.gov — NCT02763683
Locations in the U.S.
| Missouri | Washington University in St. Louis, St Louis |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.