Home › Melanoma › NCT02775643

Molecular Analysis of Childhood and Adolescent Melanocytic Lesions

Who can join

Up to age 18 · All sexes

Inclusion Criteria:

* Participant has a suspected or confirmed diagnosis of a melanocytic lesion, including:

  * Conventional or "adult-type" melanoma
  * Spitzoid melanoma/atypical Spitz tumor
  * Congenital melanoma
  * Melanoma arising in a giant congenital nevus
  * Melanocytic lesions with indeterminate biological behavior (e.g., pigment synthesizing melanomas)
* Participant was \<19 years of age at the time of diagnosis.
* Tissue is available for biologic studies.
* Participant has been enrolled on the TBANK protocol at SJCRH, or will be enrolled before any research tests are performed on their biological materials.

Exclusion Criteria:

* Ocular melanoma
* Inability or unwillingness of research participant or legal guardian to consent.
* Histologic diagnosis other than melanocytic lesion described in 3.1.1.

About the study

This is an observational, non-therapeutic study to collect clinical and molecular information of pediatric patients with childhood melanocytic lesions.

PRIMARY OBJECTIVE: To perform a comprehensive molecular analysis of samples either from paraffin embedded and/or frozen tissue from patients with pediatric melanocytic lesions (including melanoma, spitzoid melanoma, congenital melanoma, melanoma arising in giant nevi).

SECONDARY OBJECTIVE: To collect minimal information on patients treated with adjuvant or systemic therapies according to National Comprehensive Cancer Network (NCCN) guidelines.

Sponsor: St. Jude Children's Research Hospital · Participants: 500 · Started: May 31, 2016

Contact the study team

• Alberto Pappo, MD · Phone: 866-278-5835

Official record on ClinicalTrials.gov — NCT02775643

Locations in the U.S.

Conditions

• Melanoma

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.