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Corneal Elastography and Patient Specific Modeling
Who can join
Ages 16 to 80 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Any patient with keratoconus diagnosed by standard criteria, including topographic steepness, irregular astigmatism with a pattern consistent with keratoconus. * Any patient deemed a candidate for LASIK (laser vision correction) and scheduled for surgery. Exclusion Criteria: * Inability to provide informed consent, including non-English speaking (if interpreter not available) and cognitively/mentally impaired (if legal guardian not available).
About the study
The goal of this research is to develop measurement tools and simulation technology for characterizing and predicting individual responses to corneal treatments and for advancing understanding of corneal ectasia risk factors. Patients who either 1) have keratoconus and are being evaluated for corneal crosslinking or 2) have refractive error and are being evaluated for refractive surgery procedures such as LASIK will have their eyes imaged to assess their mechanical properties and will have computational simulations performed to predict the response to treatment. One aim of the study is to test the hypothesis that computational models can predict the cornea's shape changes within clinically acceptable limits of error.
What is being tested
- Optical coherence tomography (other)
Sponsor: The Cleveland Clinic · Participants: 60 · Started: 2016-05
Contact the study team
- Pamela Hoffman, MS · Phone: 216-445-5248
- Rachel Rusnak · Phone: 216-445-1256
Official record on ClinicalTrials.gov — NCT03030755
Locations in the U.S.
| Ohio | Cleveland Clinic Foundation Cole Eye Institute, Cleveland |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.