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Keratoconus clinical trials recruiting in the U.S.
17 studies for Keratoconus are recruiting participants at sites across the United States.
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Recently updated studies
Corneal Crosslinking for Treatment of Progressive Keratoconus or Corneal Ectasia
RecruitingPhase 2/3
Ages 10 to 90 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT07841470A Study to Assess Brillouin Hydration Mapping for the Evaluation of Ocular Tissues and Diseases
RecruitingObservational studyHealthy volunteers welcome
Ages 20 to 79 ยท All sexes ยท Updated Aug 25, 2026 ยท NCT07780890Evaluate the Safety and Feasibility of Same-Day Bilateral Epithelium-On Corneal Cross-Linking for Keratoconus
RecruitingPhase 4
Ages 13 and older ยท All sexes ยท Updated Jun 5, 2026 ยท NCT07629557Corneal Elastography and Patient Specific Modeling
RecruitingObservational studyHealthy volunteers welcome
Ages 16 to 80 ยท All sexes ยท Updated Jun 3, 2026 ยท NCT03030755Intacs Prescription Inserts for Keratoconus Patients
Recruiting
Ages 18 and older ยท All sexes ยท Updated Apr 9, 2026 ยท NCT02138669Placebo-controlled Study to Evaluate the Safety and Efficacy of GLK-221 Ophthalmic Solution in Subjects With Keratoconus
RecruitingPhase 2
Ages 18 to 55 ยท All sexes ยท Updated Feb 10, 2026 ยท NCT07400952Comparison of Epi-ON Corneal Collagen Crosslinking Performed Using an 18-Minute UVA Exposure vs. a 24-Minute UVA Exposure on Eyes With Ectatic Corneal Diseases
RecruitingPhase 3
Ages 8 and older ยท All sexes ยท Updated Feb 2, 2026 ยท NCT07124910Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome
RecruitingPhase 3
Ages 8 and older ยท All sexes ยท Updated Feb 2, 2026 ยท NCT07135167fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
RecruitingObservational studyHealthy volunteers welcome
Ages 8 to 35 ยท All sexes ยท Updated Dec 19, 2025 ยท NCT04439552A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia
RecruitingObservational studyHealthy volunteers welcome
Ages 20 to 75 ยท All sexes ยท Updated Nov 6, 2025 ยท NCT02118922Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia
RecruitingPhase 2
Ages 10 and older ยท All sexes ยท Updated Oct 20, 2025 ยท NCT04094090Scleral Lens Fitting Using Wide-Field OCT
RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Sep 9, 2025 ยท NCT04570020Collagen Cross-linking in Keratoconus
Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 9, 2025 ยท NCT03760432OCT in Diagnosis of Irregular Corneas
RecruitingObservational studyHealthy volunteers welcome
Ages 14 to 85 ยท All sexes ยท Updated Sep 9, 2025 ยท NCT03504800The K-Map Study, Global Prevalence of KC
RecruitingObservational studyHealthy volunteers welcome
Ages 6 to 23 ยท All sexes ยท Updated Aug 11, 2025 ยท NCT03115710Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking
RecruitingPhase 1
Ages 12 to 45 ยท All sexes ยท Updated Nov 12, 2024 ยท NCT03918408Safety and Effectiveness of the PXL-Platinum 330 System for Cornea Crosslinking in Eyes With Cornea Thinning
RecruitingPhase 2Healthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Jun 14, 2024 ยท NCT05516004From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.