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Keratoconus clinical trials recruiting in the U.S.

17 studies for Keratoconus are recruiting participants at sites across the United States.

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Recently updated studies

Corneal Crosslinking for Treatment of Progressive Keratoconus or Corneal Ectasia

RecruitingPhase 2/3
Ages 10 to 90 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT07841470

A Study to Assess Brillouin Hydration Mapping for the Evaluation of Ocular Tissues and Diseases

RecruitingObservational studyHealthy volunteers welcome
Ages 20 to 79 ยท All sexes ยท Updated Aug 25, 2026 ยท NCT07780890

Evaluate the Safety and Feasibility of Same-Day Bilateral Epithelium-On Corneal Cross-Linking for Keratoconus

RecruitingPhase 4
Ages 13 and older ยท All sexes ยท Updated Jun 5, 2026 ยท NCT07629557

Corneal Elastography and Patient Specific Modeling

RecruitingObservational studyHealthy volunteers welcome
Ages 16 to 80 ยท All sexes ยท Updated Jun 3, 2026 ยท NCT03030755

Intacs Prescription Inserts for Keratoconus Patients

Recruiting
Ages 18 and older ยท All sexes ยท Updated Apr 9, 2026 ยท NCT02138669

Placebo-controlled Study to Evaluate the Safety and Efficacy of GLK-221 Ophthalmic Solution in Subjects With Keratoconus

RecruitingPhase 2
Ages 18 to 55 ยท All sexes ยท Updated Feb 10, 2026 ยท NCT07400952

fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

RecruitingObservational studyHealthy volunteers welcome
Ages 8 to 35 ยท All sexes ยท Updated Dec 19, 2025 ยท NCT04439552

A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia

RecruitingObservational studyHealthy volunteers welcome
Ages 20 to 75 ยท All sexes ยท Updated Nov 6, 2025 ยท NCT02118922

Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia

RecruitingPhase 2
Ages 10 and older ยท All sexes ยท Updated Oct 20, 2025 ยท NCT04094090

Scleral Lens Fitting Using Wide-Field OCT

RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Sep 9, 2025 ยท NCT04570020

Collagen Cross-linking in Keratoconus

Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 9, 2025 ยท NCT03760432

OCT in Diagnosis of Irregular Corneas

RecruitingObservational studyHealthy volunteers welcome
Ages 14 to 85 ยท All sexes ยท Updated Sep 9, 2025 ยท NCT03504800

The K-Map Study, Global Prevalence of KC

RecruitingObservational studyHealthy volunteers welcome
Ages 6 to 23 ยท All sexes ยท Updated Aug 11, 2025 ยท NCT03115710

Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking

RecruitingPhase 1
Ages 12 to 45 ยท All sexes ยท Updated Nov 12, 2024 ยท NCT03918408

Safety and Effectiveness of the PXL-Platinum 330 System for Cornea Crosslinking in Eyes With Cornea Thinning

RecruitingPhase 2Healthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Jun 14, 2024 ยท NCT05516004

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.