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Brain, Blood And Clot or Tissue Registry And Collaboration
Brain, Blood And Clot or Tissue Registry And Collaboration (BACTRAC)
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria 1. All patients, Male or female, aged 18 years or older, undergoing cerebrovascular surgery/procedure at the University of Kentucky. Exclusion Criteria: 1\. Pregnant or breastfeeding females
About the study
This is a prospective open enrollment biorepository to collect and evaluate blood and tissue collected during cerebrovascular procedures, which will then be used for the purposes of identifying biological markers, inflammatory cell infiltrates, and biological states in stroke and other cerebrovascular diseases in the human condition.
The study population will include up to 1000 subjects with cerebrovascular disease or suspected cerebrovascular disease. Male and female participants 18 years of age and older will be enrolled.
This protocol covers the procurement of biological samples from patients undergoing any cerebrovascular surgery and/or neurointerventional clinical procedure at University of Kentucky. Control participants will include patients undergoing non-emergent, elective diagnostic cerebral angiography as well as patients undergoing emergent angiogram cases.
This study represents the first time that tissue, clot and blood will be evaluated for the markers, proteins, and cytokines in human subjects undergoing cerebrovascular procedures.
By starting with the human condition, the investigators aim to minimize this loss in translation. Overall, this study will have a great impact on our knowledge of stroke pathology. In essence, this could fundamentally change not only how the investigators develop treatment strategies for the stroke patient population but allow us to individualize the treatment dependent on time after stroke, age, sex, and co-morbidities. Molecular techniques that are impractical when delivered systemically could be delivered locally to impede the early inflammation.
This research aims to advance understanding of cerebrovascular disease and to support the development of improved therapies.
What is being tested
- Registry (other)
Sponsor: Justin Fraser · Participants: 1,000 · Started: May 11, 2017
Contact the study team
- Jennifer R Isaacs, MS, MS · Phone: 859-323-4738
- Justin F Fraser, MD · Phone: 859-323-0616
Official record on ClinicalTrials.gov — NCT03153683
Locations in the U.S.
| Kentucky | University of Kentucky Deparment of Neurosurgery, UK Chandler Hospital, Lexington |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.