Home › Seizures › NCT03419260

Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill Children

Who can join

1 Month – 18 Years · All sexes

Inclusion Criteria:

1. Care in the Children's Hospital of Philadelphia Pediatric ICU.
2. Clinically indicated continuous EEG monitoring.
3. Age \> 1 month to 18 years.

Exclusion Criteria:

1. Admitted for Phase 2 (intracranial) EEG monitoring.
2. Intensivist expects to discontinue technological support in the next two days given underlying medical or neurological problems.

About the study

Electrographic seizures are common in critically ill patients leading to increased use of resource-intense continuous EEG monitoring for seizure identification and management. When identified, electrographic seizures are generally treated with anti-seizure medications, but there are very limited data available regarding optimal treatment in terms of the efficacy or safety of specific anti-seizure medications or overall management strategies.

This is a single-center prospective observational study. The investigators aim to: (1) track critically ill patients undergoing clinically indicated EEG monitoring and seizure management to identify risk factors for electrographic seizures, (2) create prediction models guiding EEG monitoring resources to the patients at highest risk for seizures, and (3) evaluate our current management strategy in terms of safety.

What is being tested

• Clinically indicated EEG monitoring. (other)

Sponsor: Children's Hospital of Philadelphia · Participants: 2,500 · Started: Mar 13, 2017

Contact the study team

• Nicholas S Abend, MD · Phone: 215-590-1719

Official record on ClinicalTrials.gov — NCT03419260

Locations in the U.S.

Conditions

• Seizures
• Status Epilepticus

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.