PET Imaging CCR2 in Lung Inflammation

Inclusion Criteria:

* Men or women 21 years of age or older who have never smoked or current smokers who smoked at least 10 cigarettes per day (1/2 pack) and have smoked at least 100 cigarettes (5 packs) over the past month.
* Screening FEV1 and FVC \> 80% of predicted
* Capable of lying still and supine within the PET/CT and PET/MR scanner for \~1 hour and follow instructions for breathing protocol during the CT portion
* No illicit drug use or other inhaled drug use (including pharmacologic agents, recreational agents, or illicit drugs) within the past year
* No known history of cardiac, pulmonary, hepatic or renal disease or diabetes
* No history of claustrophobia or other preventing condition that has previously or would interfere with completion of protocol specified imaging sessions
* Able to comprehend and willing to follow instructions for the study procedures as called for by the protocol
* BMI ≤ 35

Exclusion Criteria:

* Currently enrolled in another study using an investigational drug
* Pregnancy (confirmed by urine pregnancy test)
* Active symptoms or history of cardiac, pulmonary, hepatic or renal disease or diabetes
* Currently taking any prescription medications
* Presence of an implanted device that is incompatible with CT or MRI scanning
* Creatinine \> 1.30 mg/dL, AST \> 50 Units/L, ALT \> 55 Units/L, or total bilirubin \> 1.2 mg/dL