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Targeted Transcranial Magnetic Stimulation to Improve Hippocampal-dependent Declarative Memory Abilities

RecruitingHealthy volunteers welcome

Who can join

Ages 19 and older · All sexes · Healthy volunteers welcome

Full eligibility criteria
The investigators anticipate enrolling 48 subjects total:

* 16 healthy young adults (age 19-35)
* 16 healthy older adults (demographically matched to aMCI group for age, sex, and educational attainment)
* 16 older adults diagnosed with amnestic mild cognitive impairment (aMCI)

Inclusion Criteria:

1. Adults 19 years of age and older
2. Healthy adults without history of psychiatric or neurological disease OR previous diagnosis of amnestic MCI
3. Must be able to provide informed consent
4. Must have the ability to comply with basic instructions and have the ability to sit comfortably still for TMS, neuroimaging, and other study procedures.
5. Right-handed based on self-report (pre-screening) and evaluation with a standard test.

Exclusion Criteria:

1. Individuals who have ferrous metal implanted in their body (other than in their teeth) or any other non-removable medical and/or metallic implant
2. Individuals who have increased intracranial pressure
3. Individuals who have any major medical illness (e.g., cancer, HIV+, hepatitis, heart disease)
4. Individuals who have confounding/dual diagnoses (e.g., comorbid mental illness and substance use disorder)
5. Individuals with current diagnoses of alcohol or substance abuse/dependence
6. Individuals with epilepsy, any history of seizures, or using medication that lowers seizure threshold
7. Individuals with any neurological disorder other than aMCI (e.g., stroke, traumatic brain injury)
8. Pregnant females --- as determined by urine pregnancy test --- will be excluded from this study due to uncertainty of the effects of MRI and TMS on the fetus
9. Not right-handed based on self-report (pre-screening) or evaluation with a standard test
10. Not a native English speaker.

About the study

This is a pilot study of non-invasive transcranial magnetic stimulation (TMS) to improve memory in healthy adults. It will also examine treating memory deficits in older adults with amnestic mild cognitive impairment (aMCI), a condition that frequently precedes Alzheimer's disease (AD). The study will test whether a form of non-invasive brain stimulation repetitive transcranial magnetic stimulation (rTMS) can improve memory abilities in healthy young adults, healthy older adults, and older adults with aMCI by retuning memory-related brain networks. This study is a key first step which will support the long-term goal of treating memory deficits in neurological patients. It is expected that rTMS will improve memory abilities in all participants, and that the improvements in memory will be attributable to changes in the connectivity of memory-related brain networks.

What is being tested

Sponsor: University of Nebraska · Participants: 80 · Started: Jan 1, 2019

Contact the study team

Official record on ClinicalTrials.gov — NCT03574207

Locations in the U.S.

NebraskaUniversity of Nebraska Medical Center, Omaha

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.