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Mild Cognitive Impairment clinical trials recruiting in the U.S.

233 studies for Mild Cognitive Impairment are recruiting participants at sites across the United States.

In mild cognitive impairment (MCI), you have more memory and thinking problems than others your age, but they don't interfere with your everyday life.

Cities with the most studies

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Recently updated studies

PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)

RecruitingPhase 1Healthy volunteers welcome
Ages 50 to 100 · All sexes · Updated Sep 28, 2026 · NCT07169630

Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging

RecruitingHealthy volunteers welcome
Ages 56 to 85 · All sexes · Updated Sep 28, 2026 · NCT03954899

Older Breast Cancer Patients: Risk for Cognitive Decline

RecruitingObservational studyHealthy volunteers welcome
Ages 60 to 105 · Women · Updated Sep 28, 2026 · NCT03451383

A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver Distress in Alzheimer's Disease (RESOLVE)

RecruitingPhase 4
Ages 50 and older · All sexes · Updated Sep 25, 2026 · NCT07633470

Benefits of Nicotinamide Riboside Upon Cognition and Sleep

RecruitingHealthy volunteers welcome
Ages 65 to 85 · All sexes · Updated Sep 24, 2026 · NCT05500170

A Study of LY3439539 in Participants With Alzheimer's Disease

RecruitingPhase 1
Ages 50 to 85 · All sexes · Updated Sep 24, 2026 · NCT07598370

taVNS + CCT for Neurocognitive Rehab

Recruiting
Ages 45 to 80 · All sexes · Updated Sep 23, 2026 · NCT07517237

Combating Alzheimer's Through Sleep and Exercise

RecruitingHealthy volunteers welcome
Ages 55 to 80 · All sexes · Updated Sep 23, 2026 · NCT04855630

A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)

RecruitingPhase 2
Ages 55 to 85 · All sexes · Updated Sep 22, 2026 · NCT07589595

Predicting Pre-dementia

RecruitingObservational studyHealthy volunteers welcome
Ages 55 and older · All sexes · Updated Sep 22, 2026 · NCT07516119

Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies

RecruitingPhase 3
Ages 50 to 90 · All sexes · Updated Sep 21, 2026 · NCT07177352

Music for Pain and Dementia

Recruiting
Ages 50 to 80 · All sexes · Updated Sep 21, 2026 · NCT07602283

Microbiome in Aging of Gut and Brain

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07799402

Comparing Two Acute Care Transition Programs for Older Adults and Their Family Caregivers

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07661355

PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 99 · All sexes · Updated Sep 18, 2026 · NCT04396873

Percepta for Cognitive Optimization

Recruiting
Ages 40 to 85 · All sexes · Updated Sep 17, 2026 · NCT07612449

A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)

RecruitingPhase 3
Ages 60 to 85 · All sexes · Updated Sep 17, 2026 · NCT06976203

Characterization of Dysmorphology in Subjects With Creatine Transporter Deficiency

RecruitingObservational study
Ages 2 to 40 · Men · Updated Sep 16, 2026 · NCT05600946

Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT04916210

Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium

RecruitingObservational study
Ages 70 and older · All sexes · Updated Sep 14, 2026 · NCT06052397

Study to Understand Novel Biomarkers in Researching Dementia

RecruitingObservational studyHealthy volunteers welcome
Ages 60 and older · All sexes · Updated Sep 11, 2026 · NCT06547099

Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment

RecruitingHealthy volunteers welcome
Ages 65 and older · All sexes · Updated Sep 11, 2026 · NCT07225400

Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease

RecruitingPhase 1
Ages 8 to 17 · All sexes · Updated Sep 9, 2026 · NCT07226219

Longevity Metrics AI/ML Development Study

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07808619

100-Year Human Aging Study

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT07563777

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.