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Mild Cognitive Impairment clinical trials recruiting in the U.S.
233 studies for Mild Cognitive Impairment are recruiting participants at sites across the United States.
In mild cognitive impairment (MCI), you have more memory and thinking problems than others your age, but they don't interfere with your everyday life.
Cities with the most studies
- New York City, NY23 studies
- Boston, MA21 studies
- Chicago, IL17 studies
- Baltimore, MD16 studies
- Los Angeles, CA12 studies
- Philadelphia, PA11 studies
- Miami, FL11 studies
- Birmingham, AL11 studies
- Houston, TX10 studies
- San Francisco, CA10 studies
- St. Louis, MO9 studies
- Atlanta, GA9 studies
- Durham, NC9 studies
- Washington, DC9 studies
- Gainesville, FL8 studies
- Tampa, FL8 studies
- Indianapolis, IN8 studies
- Portland, OR8 studies
- Phoenix, AZ8 studies
- Dallas, TX7 studies
- Columbus, OH7 studies
- Irvine, CA6 studies
- Farmington Hills, MI6 studies
- San Diego, CA6 studies
- Hollywood, FL6 studies
- San Antonio, TX6 studies
- Charleston, SC6 studies
- Providence, RI6 studies
- Jacksonville, FL5 studies
- West Palm Beach, FL5 studies
- Orlando, FL5 studies
- Mountain View, CA5 studies
- Austin, TX5 studies
- Ann Arbor, MI5 studies
- The Bronx, NY5 studies
- Pittsburgh, PA5 studies
- Winston-Salem, NC5 studies
- New Haven, CT5 studies
- Boulder, CO5 studies
- Seattle, WA5 studies
By state
- Alabama12 studies
- Arizona13 studies
- Arkansas3 studies
- California41 studies
- Colorado13 studies
- Connecticut9 studies
- District of Columbia5 studies
- Florida27 studies
- Georgia11 studies
- Illinois21 studies
- Indiana11 studies
- Iowa3 studies
- Maryland23 studies
- Massachusetts27 studies
- Michigan11 studies
- Minnesota6 studies
- Mississippi3 studies
- Missouri11 studies
- New Hampshire3 studies
- New Jersey9 studies
- New York31 studies
- North Carolina16 studies
- Ohio11 studies
- Oregon10 studies
- Pennsylvania13 studies
- Rhode Island6 studies
- South Carolina8 studies
- Tennessee9 studies
- Texas24 studies
- Utah4 studies
- Virginia5 studies
- Washington6 studies
Recently updated studies
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
RecruitingPhase 1Healthy volunteers welcome
Ages 50 to 100 · All sexes · Updated Sep 28, 2026 · NCT07169630Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging
RecruitingHealthy volunteers welcome
Ages 56 to 85 · All sexes · Updated Sep 28, 2026 · NCT03954899Older Breast Cancer Patients: Risk for Cognitive Decline
RecruitingObservational studyHealthy volunteers welcome
Ages 60 to 105 · Women · Updated Sep 28, 2026 · NCT03451383A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver Distress in Alzheimer's Disease (RESOLVE)
RecruitingPhase 4
Ages 50 and older · All sexes · Updated Sep 25, 2026 · NCT07633470Benefits of Nicotinamide Riboside Upon Cognition and Sleep
RecruitingHealthy volunteers welcome
Ages 65 to 85 · All sexes · Updated Sep 24, 2026 · NCT05500170A Study of LY3439539 in Participants With Alzheimer's Disease
RecruitingPhase 1
Ages 50 to 85 · All sexes · Updated Sep 24, 2026 · NCT07598370taVNS + CCT for Neurocognitive Rehab
Recruiting
Ages 45 to 80 · All sexes · Updated Sep 23, 2026 · NCT07517237Combating Alzheimer's Through Sleep and Exercise
RecruitingHealthy volunteers welcome
Ages 55 to 80 · All sexes · Updated Sep 23, 2026 · NCT04855630A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)
RecruitingPhase 2
Ages 55 to 85 · All sexes · Updated Sep 22, 2026 · NCT07589595Predicting Pre-dementia
RecruitingObservational studyHealthy volunteers welcome
Ages 55 and older · All sexes · Updated Sep 22, 2026 · NCT07516119Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
RecruitingPhase 3
Ages 50 to 90 · All sexes · Updated Sep 21, 2026 · NCT07177352Music for Pain and Dementia
Recruiting
Ages 50 to 80 · All sexes · Updated Sep 21, 2026 · NCT07602283Microbiome in Aging of Gut and Brain
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07799402Comparing Two Acute Care Transition Programs for Older Adults and Their Family Caregivers
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07661355PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 99 · All sexes · Updated Sep 18, 2026 · NCT04396873Percepta for Cognitive Optimization
Recruiting
Ages 40 to 85 · All sexes · Updated Sep 17, 2026 · NCT07612449A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)
RecruitingPhase 3
Ages 60 to 85 · All sexes · Updated Sep 17, 2026 · NCT06976203Characterization of Dysmorphology in Subjects With Creatine Transporter Deficiency
RecruitingObservational study
Ages 2 to 40 · Men · Updated Sep 16, 2026 · NCT05600946Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT04916210Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium
RecruitingObservational study
Ages 70 and older · All sexes · Updated Sep 14, 2026 · NCT06052397Study to Understand Novel Biomarkers in Researching Dementia
RecruitingObservational studyHealthy volunteers welcome
Ages 60 and older · All sexes · Updated Sep 11, 2026 · NCT06547099Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment
RecruitingHealthy volunteers welcome
Ages 65 and older · All sexes · Updated Sep 11, 2026 · NCT07225400Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease
RecruitingPhase 1
Ages 8 to 17 · All sexes · Updated Sep 9, 2026 · NCT07226219Longevity Metrics AI/ML Development Study
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07808619100-Year Human Aging Study
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT07563777From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.