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Mild Cognitive Impairment clinical trials recruiting in the U.S.

237 studies for Mild Cognitive Impairment are recruiting participants at sites across the United States.

In mild cognitive impairment (MCI), you have more memory and thinking problems than others your age, but they don't interfere with your everyday life.

Cities with the most studies

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Recently updated studies

PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)

RecruitingPhase 1Healthy volunteers welcome
Ages 50 to 100 · All sexes · Updated Nov 13, 2026 · NCT07169630

Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease

RecruitingHealthy volunteers welcome
Ages 18 to 89 · All sexes · Updated Nov 13, 2026 · NCT04800588

Adaptango Performance PRocess for Older Adults Community reHabilitation

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT07824128

Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)

Recruiting
Ages 18 to 60 · All sexes · Updated Nov 13, 2026 · NCT06413173

Designing a Spatial Navigation Intervention Protocol Informed by Region-specific Brain Activation for Mild Cognitive Impairment

RecruitingHealthy volunteers welcome
Ages 65 and older · All sexes · Updated Nov 12, 2026 · NCT07225400

Prediction and Prevention of Postoperative Mortality and Morbidity

Recruiting
Ages 65 and older · All sexes · Updated Nov 12, 2026 · NCT06042413

Tennessee Alzheimer's Project

RecruitingObservational studyHealthy volunteers welcome
Ages 60 and older · All sexes · Updated Nov 10, 2026 · NCT05372172

CMN LIFU for Enhanced Amyloid Reduction (CLEART Study)

Recruiting
Ages 65 and older · All sexes · Updated Nov 9, 2026 · NCT07866768

HEARS-NPS: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms

RecruitingHealthy volunteers welcome
Ages 60 to 100 · All sexes · Updated Nov 6, 2026 · NCT06930560

Flutemetamol F 18 Injection Formulation Comparison

RecruitingPhase 2
Ages 50 to 110 · All sexes · Updated Nov 5, 2026 · NCT07873463

Feasibility of A Smartphone Application Intervention in Community Settings: A Pretest-Posttest Pilot Study

RecruitingHealthy volunteers welcome
Ages 50 to 100 · All sexes · Updated Nov 5, 2026 · NCT07313540

Neurobehavioral Changes Following Spaceflight Stressors

RecruitingHealthy volunteers welcome
Ages 21 to 60 · All sexes · Updated Nov 5, 2026 · NCT07293494

Treating Insomnia in Mild Cognitive Impairment

Recruiting
Ages 60 and older · All sexes · Updated Nov 5, 2026 · NCT06687161

Telehealth-Adapted Compensatory Training and Intervention for Cognition

Recruiting
Ages 65 to 84 · All sexes · Updated Nov 5, 2026 · NCT07366346

A Study of LY3439539 in Participants With Alzheimer's Disease

RecruitingPhase 1
Ages 50 to 85 · All sexes · Updated Nov 4, 2026 · NCT07598370

A Study of Donanemab (LY3002813) in Participants With Early Cognitive Decline (TRAILBLAZER-ALZ 7)

RecruitingPhase 2
Ages 55 to 85 · All sexes · Updated Nov 4, 2026 · NCT07589595

Rural Veteran and Care Partner Walking Program

RecruitingHealthy volunteers welcome
Ages 19 to 90 · All sexes · Updated Nov 3, 2026 · NCT07914218

HOBSCOTCH-MS-Efficacy Trial

Recruiting
Ages 20 to 75 · All sexes · Updated Nov 2, 2026 · NCT06951919

PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 99 · All sexes · Updated Nov 2, 2026 · NCT04396873

HOBSCOTCH-YOUTH and Young Adults

Recruiting
Ages 13 to 29 · All sexes · Updated Nov 2, 2026 · NCT07735715

A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease

RecruitingPhase 1
Ages 50 to 85 · All sexes · Updated Oct 29, 2026 · NCT06297590

ME/CFS Brain Fog: Cognitive Rehabilitation Trial

Recruiting
Ages 18 and older · All sexes · Updated Oct 29, 2026 · NCT07523113

Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab

RecruitingPhase 2
Ages 25 to 50 · All sexes · Updated Oct 27, 2026 · NCT06136546

A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease

RecruitingPhase 3
Ages 60 to 85 · All sexes · Updated Oct 27, 2026 · NCT06976216

Combating Alzheimer's Through Sleep and Exercise

RecruitingHealthy volunteers welcome
Ages 55 to 80 · All sexes · Updated Oct 27, 2026 · NCT04855630

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.