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Radiotracer-Based Perfusion Imaging of Patients With Peripheral Arterial Disease

Radiotracer Imaging of Skeletal Muscle Perfusion in Patients With Peripheral Artery Disease

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria for Patients with Peripheral Artery Disease:

1. At least 18 years of age
2. Evidence of significant obstructive disease for one or multiple lower extremity arteries, as identified by prior ABI, TBI, CT angiography, ultrasound, or MR imaging.

Exclusion Criteria for Patients with Peripheral Artery Disease:

1. Unable to give informed consent or follow-up
2. Pregnant or nursing
3. Under the age of 18
4. No history of peripheral artery disease

Inclusion Criteria for Healthy Control Subjects:

1. At least 18 years of age
2. No evidence or prior diagnosis of peripheral artery disease based on chart review and standard vascular screening.

Exclusion Criteria for Healthy Control Subjects:

1. Unable to give informed consent of follow-up
2. Pregnant or nursing
3. Under the age of 18
4. History of peripheral artery disease

About the study

The aim of this clinical study is to 1) establish a healthy database for nuclear perfusion imaging of the lower extremities and 2) assess the prognostic value of radiotracer-based perfusion imaging for predicting clinical outcomes in patients with peripheral artery disease (PAD) who are undergoing lower extremity revascularization procedures. We hypothesize that radiotracer imaging of the lower extremities will provide a sensitive non-invasive imaging tool for quantifying regional abnormalities in skeletal muscle perfusion and evaluating responses to medical treatment.

What is being tested

• SPECT/CT perfusion imaging (diagnostic test)
• PET/CT perfusion imaging (diagnostic test)

Sponsor: Nationwide Children's Hospital · Participants: 192 · Started: Feb 17, 2017

Contact the study team

• Mitchel R Stacy, Ph.D. · Phone: 614-355-5836

Official record on ClinicalTrials.gov — NCT03622359

Locations in the U.S.

Conditions

• Peripheral Arterial Disease
• Diabetes
• Chronic Limb-Threatening Ischemia

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.