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Peripheral Arterial Disease clinical trials recruiting in the U.S.

69 studies for Peripheral Arterial Disease are recruiting participants at sites across the United States.

Peripheral arterial disease (PAD) happens when there is a narrowing of the blood vessels outside of your heart. Learn about symptoms and treatment.

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Recently updated studies

EVERO Drug-coated Balloon (DCB) Randomized Trial

Recruiting
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07144150

Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With Peripheral Artery Disease

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07318610

Efficacy and Safety of Orforglipron in Participants With Peripheral Artery Disease

RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07223593

Detecting Peripheral Artery Disease With the Pulse

RecruitingHealthy volunteers welcome
Ages 19 and older · All sexes · Updated Sep 17, 2026 · NCT07226193

Advanta VXT and Flixene PMCF Registry

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT07161583

Intervascular Post-Market Clinical Follow-Up (PMCF) Registry

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT07322913

Personalizing Thromboprophylaxis for Patients With Peripheral Artery Disease

Recruiting
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT07613840

Community-based Exercise Following Revascularization for PAD

Recruiting
Ages 40 to 90 · All sexes · Updated Sep 9, 2026 · NCT04252950

The Golazo® Peripheral Atherectomy System for a Safe and Effective Atherectomy (GREAT Trial)

Recruiting
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT06321575

Leg Heat Therapy in Peripheral Artery Disease

Recruiting
Ages 50 and older · All sexes · Updated Aug 17, 2026 · NCT05465070

CRUSH PAD: Real-world Outcomes Following Use of Shockwave Intravascular Lithotripsy (IVL) Technology in Calcified Common Femoral Lesions

RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 14, 2026 · NCT05145478

Case-Specific Health Care Professional Clinical Survey of Liberant™ Thrombectomy System

RecruitingObservational study
Ages 22 and older · All sexes · Updated Aug 11, 2026 · NCT07335341

Response to Exercise and Nitric Oxide in PAD

RecruitingPhase 2
Ages 50 and older · All sexes · Updated Jul 27, 2026 · NCT06657976

Vascular Trial Associated Registry Pilot

RecruitingPhase 4
Ages 45 and older · All sexes · Updated Jul 16, 2026 · NCT07076082

Intravascular Ultrasound Imaging Guidance for Optimal Revascularization of Limb Arteries

Recruiting
Ages 18 and older · All sexes · Updated Jul 9, 2026 · NCT07353905

Use of Thermal Imaging Camera to Assess Perfusion Before and After Vascular Intervention

RecruitingObservational study
Ages 18 to 99 · All sexes · Updated Jul 2, 2026 · NCT06544135

The Pharmacokinetics and Pharmacodynamics Study of Evategrel CG-0255 Besylate)and Plavix® in Healthy Participants

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Jun 29, 2026 · NCT07619885

Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease

RecruitingEarly phase 1Healthy volunteers welcome
Ages 50 to 75 · All sexes · Updated Jun 24, 2026 · NCT06319339

The THOR IDE Study

Recruiting
Ages 18 and older · All sexes · Updated Jun 11, 2026 · NCT05916950

The Effects of a Novel, Non-ischemic and Pain-free Exercise Intervention in Peripheral Artery Disease

Recruiting
Ages 40 and older · All sexes · Updated May 29, 2026 · NCT05712395

The COCOA-PAD II Trial

RecruitingPhase 3
Ages 55 and older · All sexes · Updated May 28, 2026 · NCT04794530

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.