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Collagen Cross-linking in Keratoconus
Clinical Trial of Laser Custom Corneal Collagen Cross-Linking in Keratoconus
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Diagnosis of keratoconus * Minimum corneal thickness of 410 microns Exclusion Criteria: * Inability to maintain fixation for OCT imaging * Inability to commit to required study visits * Inability to give informed consent * Eyes with concurrent retinal diseases, glaucoma, or other eye conditions that may limit the visual outcome after surgery * Mature cataracts if found to limit visual potential to worse than 20/40
About the study
Optical Coherence Tomography (OCT) devices are non-contact instruments that can measure the depth of scars, other causes of cloudiness of the cornea, and degree of corneal thinning in patients with keratoconus. Laser Custom Corneal Collagen Cross-linking (CXL) significantly decreases corneal aberrations and improves vision. This study will use OCT-guided setting for the lasers used in the corneal smoothing portion of the laser custom CXL procedure to assess the affect on visual outcomes.
What is being tested
- Laser Custom Corneal Collagen Cross-Linking (procedure)
Sponsor: Oregon Health and Science University · Participants: 100 · Started: Jun 20, 2018
Contact the study team
- Denzil Romfh, OD · Phone: 503-494-4351
- Humberto Martinez, COT · Phone: 503-494-7712
Official record on ClinicalTrials.gov — NCT03760432
Locations in the U.S.
| Oregon | Oregon Health & Science University, Portland |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.