Chemical Peels and Fractional Laser on IGF-1 Levels in Skin

Inclusion Criteria:

* Male and female subjects \>55 years old
* Fitzpatrick type I-II
* Able to provide informed consent.
* Cutaneous photodamage of 3 or above on the Larnier photodamage scale (see Appendix).

Exclusion Criteria:

* Prior laser or peel treatment in the area evaluated in the current study in the past year.
* Currently taking immunosuppressant medications known to interfere wound healing or anti-inflammatory medications (such as NSAIDs, or steroids).
* Subjects who have underlying diseases that could alter wound healing response (such as Diabetes).
* Currently taking insulin.
* History of substance abuse, mental dysfunction, or other factors limiting ability to cooperate with study.
* History of abnormal scarring such as Keloids.
* History of vitiligo.
* Allergy or sensitivity or allergy to topical anesthesia
* Inability to use sunscreen.
* History of smoking in the last 10 years
* Scar or prior surgery in the area of treatment.
* Use of isotretinoin in the prior 6 months
* Subjects who have bleeding disorders or who are taking anticoagulants