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PAIN: A Project Assessing the Impact of a Novel Cannabinoid Product

RecruitingPhase 2

Who can join

Ages 21 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* Subject has provided informed consent
* Subject is 21 or older
* Subject is fluent in English
* Subject endorses a musculoskeletal chronic pain condition including, but not limited to, chronic pain due to injury, arthritis (including osteoarthritis and rheumatoid arthritis), bursitis, etc.

Exclusion Criteria:

* Non-fluent English speakers
* Estimated IQ \< 75
* A history of head injury or loss of consciousness greater than 5 minutes
* Currently uses CBD products regularly
* Female subjects will be excluded if they have a positive urine pregnancy test, are trying to become pregnant, or are currently breastfeeding
* Presence of a serious or unstable medical illness, including liver, kidney, or cardiovascular disease (hyper/hypotension, cardiac disorders), or neurological disorder (including seizure disorder)
* Primary neuropathic pain or cancer-related pain; patients experiencing neuropathic pain secondary to musculoskeletal pain will be allowed to enter the study
* Disclosure of a genetic polymorphism affecting CYP2C9 function

About the study

This study is a clinical trial of a high-cannabidiol (CBD) sublingual product compared to placebo for 9 weeks in patients with chronic pain conditions. The study will assess the impact of CBD on chronic pain symptoms, conventional medication use, clinical state, quality of life, cognition, and biomarkers.

What is being tested

Sponsor: Staci Gruber, Ph.D. · Participants: 25 · Started: Jun 27, 2024

Contact the study team

Official record on ClinicalTrials.gov — NCT03984565

Locations in the U.S.

MassachusettsMcLean Hospital, Belmont

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.