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Chronic Pain clinical trials recruiting in the U.S.
180 studies for Chronic Pain are recruiting participants at sites across the United States.
Chronic pain lasts longer than three months or the time in which you should have healed. It is not always curable, but treatments can help.
Cities with the most studies
- Boston, MA18 studies
- Chicago, IL13 studies
- Baltimore, MD9 studies
- Houston, TX8 studies
- Pittsburgh, PA7 studies
- San Francisco, CA7 studies
- Minneapolis, MN7 studies
- Mountain View, CA7 studies
- New Haven, CT7 studies
- Durham, NC6 studies
- New York City, NY6 studies
- Indianapolis, IN5 studies
- Cincinnati, OH5 studies
- San Diego, CA5 studies
- Salt Lake City, UT5 studies
- Orlando, FL5 studies
- Cleveland, OH5 studies
- Washington, DC5 studies
- Seattle, WA4 studies
- Los Angeles, CA4 studies
- Aurora, CO4 studies
- Winston-Salem, NC4 studies
- Tallahassee, FL4 studies
- Rochester, NY4 studies
- Charleston, SC4 studies
- Birmingham, AL4 studies
- Phoenix, AZ4 studies
- New Orleans, LA4 studies
- Newton, MA4 studies
- Ann Arbor, MI4 studies
- Tulsa, OK3 studies
- Miami, FL3 studies
- San Antonio, TX3 studies
- Greenville, SC3 studies
- The Bronx, NY3 studies
- Gainesville, FL3 studies
- St. Petersburg, FL3 studies
- Ocala, FL3 studies
- Philadelphia, PA3 studies
By state
- Alabama5 studies
- Arizona6 studies
- California27 studies
- Colorado6 studies
- Connecticut10 studies
- District of Columbia4 studies
- Florida15 studies
- Georgia4 studies
- Illinois14 studies
- Indiana6 studies
- Louisiana5 studies
- Maryland10 studies
- Massachusetts25 studies
- Michigan10 studies
- Minnesota10 studies
- Missouri4 studies
- New York17 studies
- North Carolina11 studies
- Ohio14 studies
- Oklahoma3 studies
- Oregon4 studies
- Pennsylvania14 studies
- South Carolina8 studies
- Tennessee3 studies
- Texas15 studies
- Utah5 studies
- Virginia3 studies
- Washington9 studies
Recently updated studies
RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT01719055Post Market Evaluation of Real World Outcomes and Durability to Support Implantable Inceptiv™ Spinal Cord Stimulation Therapy
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07507422Neural Correlates and Behavioral Impact of Withdrawal-induced Hyperalgesia Among People Who Smoke With and Without Chronic Pain
Recruiting
Ages 21 to 65 · All sexes · Updated Nov 12, 2026 · NCT06983678Patient Retrospective Outcomes (PRO)
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT01550575Managing Pain Using Optimized Sequences by Adjusting Parameters With Independent Current Control
Recruiting
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07190807LIFU for Chronic Pain and Generalized Anxiety Disorder
Recruiting
Ages 18 to 65 · All sexes · Updated Nov 9, 2026 · NCT07686354Empowered Relief® for Cancer Survivors With Chronic Pain
Recruiting
Ages 18 to 120 · All sexes · Updated Nov 6, 2026 · NCT07578376Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial
Recruiting
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT06565416ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain
RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT06442566A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain
RecruitingPhase 2
Ages 40 and older · All sexes · Updated Nov 4, 2026 · NCT07641517A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic Low Back Pain
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07641504Chromatic Retinal Stimulation to Reduce Chronic Pain and Pain Sensitivity
Recruiting
Ages 18 to 65 · All sexes · Updated Nov 2, 2026 · NCT05956067Dietary Intervention for Migraine Relief
Recruiting
Ages 18 to 75 · All sexes · Updated Oct 30, 2026 · NCT07360405VR and Cooled Genicular Nerve Radio Frequency Ablation for Chronic Knee Pain
Recruiting
Ages 18 and older · All sexes · Updated Oct 29, 2026 · NCT06336447Sana Device for Post-Treatment Lyme Disease Syndrome Chronic Pain
Recruiting
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT06655844Reducing Chronic Pain Following Cesarean Delivery
Recruiting
Ages 18 and older · Women · Updated Oct 28, 2026 · NCT07799883Studying Melatonin and Recovery in Teens
Recruiting
Ages 12 to 18 · All sexes · Updated Oct 27, 2026 · NCT06093477Focused Ultrasound Stimulation for the Treatment of Chronic Pain
Recruiting
Ages 22 to 80 · All sexes · Updated Oct 27, 2026 · NCT07801443A Study of Cebranopadol for Opioid Withdrawal Symptoms in Adults With Chronic Pain
RecruitingPhase 2
Ages 18 to 65 · All sexes · Updated Oct 23, 2026 · NCT07874620Evaluation of the PACE/PACENET BHL Clinical Program
RecruitingObservational study
Ages 65 and older · All sexes · Updated Oct 22, 2026 · NCT02463266Cannabidiol in Opioid Use Disorder and Chronic Pain With Buprenorphine
RecruitingEarly phase 1
Ages 18 to 70 · All sexes · Updated Oct 21, 2026 · NCT07886606Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance
RecruitingPhase 4
Ages 45 to 80 · All sexes · Updated Oct 21, 2026 · NCT07759336Feasibility and Effects of Noninvasive Brain Stimulation on Pain Perception in People With Fibromyalgia
Recruiting
Ages 18 to 65 · All sexes · Updated Oct 21, 2026 · NCT07644221Overlapping Pain Trajectory Study
RecruitingObservational studyHealthy volunteers welcome
Ages 10 to 19 · All sexes · Updated Oct 20, 2026 · NCT05752396Biopsychosocial Risk Influences on the Development and Generation of Early-Onset Chronic Pain
RecruitingObservational study
Ages 14 to 26 · All sexes · Updated Oct 16, 2026 · NCT07602595From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.