Skeletal Muscle Energetics and Fatiguability in Older Individuals
RecruitingObservational studyHealthy volunteers welcome
Who can join
Ages 60 to 90 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Participants who are \>= 60 years of age * HIV serostatus positive participants on stable antiretroviral therapy (ART) (no regimen change in last month) with undetectable HIV viral load (\<100 copies). * HIV serostatus negative participants Exclusion Criteria: * Unable to understand the risks, benefits, and alternatives of participation and give meaningful consent * Contraindications to MRI * Significant cardiovascular, pulmonary or musculoskeletal or orthopedic disease that significantly limits exercise capacity * Significant lower extremity peripheral vascular disease. * Weight greater than 350 lbs * Cognitive or speech impairments that would limit completion of questionnaires or fatigue reporting.
About the study
The investigators are studying whether metabolic abnormalities in calf (leg) muscle in older people with and others without HIV are associated with decreased abilities to exercise.
Sponsor: Johns Hopkins University · Participants: 200 · Started: Sep 5, 2019
Contact the study team
- Maria Esteban, RN, BSN · Phone: 410-955-1160
- Tricia Steinberg, RN, MSN · Phone: 443-287-3469
Official record on ClinicalTrials.gov — NCT04142047
Locations in the U.S.
| Maryland | Johns Hopkins Hospital, Baltimore |
Conditions
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.