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HIV clinical trials recruiting in the U.S.

137 studies for HIV are recruiting participants at sites across the United States.

HIV (human immunodeficiency virus) attacks the body’s immune system. There is no cure but it can be treated with medicines. To know if you have HIV, get tested.

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Recently updated studies

Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman Disease

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT03300830

Viral Load in Blood and Lymph Tissues in People Living With HIV

RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 100 · All sexes · Updated Sep 28, 2026 · NCT00001316

Specimen Collections From Participants With HIV Infection, KSHV Infection, Viral-Related Pre-malignant Lesions and Cancer

RecruitingObservational study
Ages 18 to 120 · All sexes · Updated Sep 28, 2026 · NCT00006518

Leukapheresis Procedures to Obtain Plasma and Lymphocytes for Research Studies on Antiretroviral Naive HIV-1 Research Participants

RecruitingObservational study
Ages 18 to 120 · All sexes · Updated Sep 28, 2026 · NCT00039689

HIV and Alcohol Research Center Focused on Polypharmacy (HARP) Pilot 2 (2nd HARP Pilot Intervention)

RecruitingPhase 1
Ages 50 and older · All sexes · Updated Sep 25, 2026 · NCT06513819

El Camino HIV Prevention and Care Study

Recruiting
Ages 18 and older · Men · Updated Sep 22, 2026 · NCT07834853

Leukapheresis to Obtain Plasma or Lymphocytes for Studies of HIV-infected Patients, Including Long-term Non-progressors

RecruitingObservational study
Ages 18 to 100 · All sexes · Updated Sep 22, 2026 · NCT00029445

ADELANTE: A Randomized Controlled Trial to Improve Engagement in Care for Latinos With HIV

Recruiting
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06274632

Imaging and Biopsy of People With HIV-1 Undergoing Analytic Treatment Interruption

RecruitingPhase 2
Ages 18 to 100 · All sexes · Updated Sep 22, 2026 · NCT05419024

A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)

RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07266831

A Seek, Test, and Treat Intervention to Reduce Chlamydia Trachomatis Disparities

RecruitingHealthy volunteers welcome
Ages 15 to 26 · All sexes · Updated Sep 21, 2026 · NCT06428643

The TAIL-PrEP Study

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT06868641

Pomalidomide and Nivolumab in People With Virus-Associated Malignancies With or Without HIV

RecruitingPhase 1
Ages 18 to 99 · All sexes · Updated Sep 17, 2026 · NCT04902443

Couples Motivational Interviewing to Reduce Drug Use and HIV Risk in Vulnerable Male Couples

RecruitingHealthy volunteers welcome
Ages 18 to 55 · Men · Updated Sep 17, 2026 · NCT06307977

A Remotely Delivered Tai Chi/Qigong Intervention for Older People Living With HIV

Recruiting
Ages 50 to 75 · All sexes · Updated Sep 16, 2026 · NCT06586619

Implementation Study of Lenacapavir Pre-exposure Prophylaxis for HIV Prevention

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07473778

Observational Pharmaco-Epidemiology Research & Analysis

RecruitingObservational studyHealthy volunteers welcome
Ages 0 and older · All sexes · Updated Sep 11, 2026 · NCT03813862

PRIDE III Prison Interventions and HIV Prevention Collaboration

Recruiting
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06962033

Very Early Intensive Treatment of Infants Living With HIV to Achieve HIV Remission

RecruitingPhase 1/2
48 Hours · All sexes · Updated Sep 9, 2026 · NCT02140255

Development and Evaluation of a Virtual Reality Tool for At-Risk Trauma-Exposed Young People

RecruitingHealthy volunteers welcome
Ages 15 to 30 · All sexes · Updated Sep 9, 2026 · NCT05816083

SCOPE: Observational Study of the Consequences of the Protease Inhibitor Era

RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT00187512

Cytotoxic T Lymphocytes in Treating Patients With Malignancies With BK and/or JC Virus

RecruitingPhase 2
All ages · All sexes · Updated Sep 4, 2026 · NCT02479698

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.