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HIV clinical trials recruiting in the U.S.

131 studies for HIV are recruiting participants at sites across the United States.

HIV (human immunodeficiency virus) attacks the body’s immune system. There is no cure but it can be treated with medicines. To know if you have HIV, get tested.

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Recently updated studies

A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study)

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07202546

Clinical and Immunologic Monitoring of Patients With Known or Suspected HIV Infection

RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT00789009

Mindfulness and Behavior Change to Improve Cardiovascular Health of Older People With HIV

RecruitingHealthy volunteers welcome
Ages 50 and older · All sexes · Updated Nov 10, 2026 · NCT06001814

Imaging and Biopsy of People With HIV-1 Undergoing Analytic Treatment Interruption

RecruitingPhase 2
Ages 18 to 100 · All sexes · Updated Nov 10, 2026 · NCT05419024

Leukapheresis Procedures to Obtain Plasma and Lymphocytes for Research Studies on Antiretroviral Naive HIV-1 Research Participants

RecruitingObservational study
Ages 18 to 120 · All sexes · Updated Nov 10, 2026 · NCT00039689

Psilocybin Therapy for Methamphetamine Use Disorder and HIV

RecruitingPhase 2
Ages 25 to 64 · All sexes · Updated Nov 9, 2026 · NCT07756736

Peer Behavioral Activation Utilization to Improve Substance Use and HIV Outcomes in People Receiving Long Acting Injectable-PrEP/ART (PUSH)

RecruitingHealthy volunteers welcome
Ages 18 to 88 · All sexes · Updated Nov 9, 2026 · NCT06501781

The Trans-Led Care Study

Recruiting
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT06880705

First Time in Human Study of Long Acting VH4524184 Formulations

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Nov 5, 2026 · NCT06310551

A Study to Investigate Pharmacokinetics, Safety and Tolerability of Long-Acting Cabotegravir Plus Recombinant Human Hyaluronidase PH20 in Healthy Adult Participants

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Nov 4, 2026 · NCT05418868

A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)

RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07266831

Natural History Study of Progressive Multifocal Leukoencephalopathy (PML)

RecruitingObservational studyHealthy volunteers welcome
Ages 2 to 120 · All sexes · Updated Oct 29, 2026 · NCT01730131

Precision Microbiota Interventions for Senoreduction Trial

RecruitingPhase 1/2
Ages 40 and older · All sexes · Updated Oct 29, 2026 · NCT07462767

Leukapheresis to Obtain Plasma or Lymphocytes for Studies of HIV-infected Patients, Including Long-term Non-progressors

RecruitingObservational study
Ages 18 to 100 · All sexes · Updated Oct 27, 2026 · NCT00029445

Dasatinib for HIV-1 Reservoir Reduction

RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT07342491

Doravirine (DOR) in Human Immunodeficiency Virus (HIV)-Infected Children Aged 4 Weeks to <12 Years and <45 kg (MK-1439-066)

RecruitingPhase 2
4 Weeks – 11 Years · All sexes · Updated Oct 27, 2026 · NCT04375800

Assessing Pharmacy Technician Educational Training for the Provision of Over-the-Counter Hearing Aids in Rural Alabama and Mississippi Pharmacies

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 26, 2026 · NCT06864273

Screen Smart: Using Digital Health to Improve HIV Screening and Prevention

RecruitingHealthy volunteers welcome
Ages 15 to 21 · All sexes · Updated Oct 23, 2026 · NCT06003192

Implementation Study of Lenacapavir Pre-exposure Prophylaxis for HIV Prevention

RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 21, 2026 · NCT07473778

A Study to Investigate Pharmacokinetics (PK), Safety, and Tolerability of VH4367310 in Healthy Adult Participants

RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Oct 20, 2026 · NCT07818915

Enhancing the Organizational Social Context to Improve Viral Suppression and Retention in HIV Care

Recruiting
Ages 18 and older · All sexes · Updated Oct 19, 2026 · NCT06462807

PDS01ADC Monotherapy and in Combination With M7824 in Advanced Kaposi Sarcoma

RecruitingPhase 1/2
Ages 18 to 99 · All sexes · Updated Oct 16, 2026 · NCT04303117

Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman Disease

RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 16, 2026 · NCT03300830

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.