Home › Appendicitis › NCT04168866

Operative Versus Non-Operative Management for Appendicitis With Abscess or Phlegmon

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

1\. Complicated appendicitis with presumed perforation on (computer tomography) CT scan AND phlegmon or abscess greater than 2 centimeter (cm).

Exclusion Criteria:

1. Antibiotic therapy greater than 24 hours prior to considering for enrollment.
2. Attempted drainage before randomization
3. Pregnancy
4. Antibiotic allergy requiring the use of something other than a beta-lactam or quinolone based therapy.
5. Previous major intra-abdominal surgery by laparotomy
6. Hospitalization within 2 weeks of randomization
7. Presence of septic shock on admission.
8. Mechanical ventilation
9. Acute renal failure requiring dialysis

About the study

The investigators aim to determine if early operative intervention is superior to non-operative management for adult patients with computerized tomography (CT)-proven complicated appendicitis with phlegmon or abscess.

What is being tested

• Operative management (procedure)
• Drainage or antibiotics (other)

Sponsor: Yale University · Participants: 180 · Started: Mar 11, 2020

Contact the study team

• Kevin Schuster, MD, MPH · Phone: 203 785 2572

Official record on ClinicalTrials.gov — NCT04168866

Locations in the U.S.

Conditions

• Appendicitis

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.