Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination
RecruitingEarly phase 1Healthy volunteers welcome
Who can join
Ages 21 to 45 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Individuals fluent in English will participate. * Must report recreational use of opioids. * Be within 20% of their ideal body weight. * Are not currently experiencing chronic pain (pain on most days during the past 3 months) * Have a systolic blood pressure of \<=140 and diastolic blood pressure of \<= 90, and a heart rate \<= 90 beats per minute. * Participants must also have a normal electrocardiogram (EKG) reading and bloodwork indicating no major health contraindications. Exclusion criteria: * Significant current physical disease or major psychiatric disorder. * No self-reported current interest in drug abuse treatment. * Women who are pregnant or nursing. * Any comorbid illicit substance use disorders or current clinically significant withdrawal for any abused drug excluding nicotine and caffeine. * Any conditions that preclude safety in the MRI scanner, such as: implanted electrical devices (e.g., cardiac pacemaker, neurostimulator); implanted metallic clips or pins (e.g., aneurysm clip); a history of working with metal (unless able to demonstrate participant is MRI safe), and claustrophobia.
About the study
Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, the investigators will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, decision-making, and activation of different neural substrates.
What is being tested
- OxyCODONE 5 mg Oral Tablet (drug)
- Oxytocin nasal spray (drug)
- Placebo Oxycodone (other)
- Placebo oxytocin (other)
- OxyCODONE 2.5 mg Oral Tablet (drug)
Sponsor: University of Florida · Participants: 45 · Started: Sep 2, 2021
Contact the study team
- Lauren Nieder · Phone: 352-294-1067
Official record on ClinicalTrials.gov — NCT04218409
Locations in the U.S.
| Florida | University of Florida, Gainesville |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.