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Pain clinical trials recruiting in the U.S.
205 studies for Pain are recruiting participants at sites across the United States.
Pain is a feeling triggered in the nervous system. You may feel it as a prick, tingle, sting, burn, or ache. Read about the causes and what can help.
Cities with the most studies
- Washington, DC15 studies
- Durham, NC15 studies
- Boston, MA14 studies
- New York City, NY11 studies
- Houston, TX10 studies
- New Haven, CT9 studies
- Pittsburgh, PA9 studies
- Los Angeles, CA9 studies
- San Diego, CA9 studies
- Baltimore, MD8 studies
- Salt Lake City, UT8 studies
- Seattle, WA7 studies
- Atlanta, GA6 studies
- Chicago, IL6 studies
- Gainesville, FL6 studies
- Indianapolis, IN5 studies
- Cincinnati, OH5 studies
- Greenburgh, NY5 studies
- St. Louis, MO5 studies
- Charlottesville, VA4 studies
- Ann Arbor, MI4 studies
- Birmingham, AL4 studies
- Charleston, SC4 studies
- Tallahassee, FL4 studies
- Mountain View, CA4 studies
- New Rochelle, NY4 studies
- Minneapolis, MN4 studies
- Edison, NJ4 studies
- Staten Island, NY4 studies
- San Antonio, TX4 studies
- Rochester, NY3 studies
- Aurora, CO3 studies
- Nashville, TN3 studies
- Austin, TX3 studies
- Queens, NY3 studies
- The Bronx, NY3 studies
- San Francisco, CA3 studies
- Miami, FL3 studies
- Cleveland, OH3 studies
- Philadelphia, PA3 studies
By state
- Alabama6 studies
- Arizona3 studies
- California30 studies
- Colorado7 studies
- Connecticut10 studies
- District of Columbia9 studies
- Florida21 studies
- Georgia10 studies
- Illinois10 studies
- Indiana5 studies
- Kansas3 studies
- Maryland15 studies
- Massachusetts16 studies
- Michigan6 studies
- Minnesota5 studies
- Missouri4 studies
- New Jersey10 studies
- New York24 studies
- North Carolina20 studies
- Ohio11 studies
- Oklahoma3 studies
- Oregon4 studies
- Pennsylvania14 studies
- South Carolina5 studies
- Tennessee6 studies
- Texas17 studies
- Utah8 studies
- Virginia9 studies
- Washington9 studies
- Wisconsin4 studies
Recently updated studies
Sociocultural & Biobehavioral Influences on Pain Expression and Assessment
RecruitingHealthy volunteers welcome
Ages 18 to 60 ยท All sexes ยท Updated Sep 28, 2026 ยท NCT03258580An Open-Label, Safety and Efficacy Study of Cebranopadol in Participants With Acute Pain With Surgical or Non-Surgical Origin
RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Sep 28, 2026 ยท NCT07845071Chronic Postsurgical Pain
RecruitingObservational study
Ages 5 to 17 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT05764681Neural and Psychological Mechanisms of Pain Perception
RecruitingHealthy volunteers welcome
Ages 18 to 50 ยท All sexes ยท Updated Sep 23, 2026 ยท NCT02446262Enhanced Pain Coping in Cancer (EPIC): A Study of Managing Treatment-Related Joint Pain in Breast Cancer Survivors
RecruitingPhase 2
Ages 18 and older ยท Women ยท Updated Sep 22, 2026 ยท NCT06728579Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort
RecruitingEarly phase 1
Ages 18 to 50 ยท All sexes ยท Updated Sep 18, 2026 ยท NCT06472622Transcutaneous Electrical Nerve Stimulation for Pain Mitigation During Intrauterine Device Placement
Recruiting
Ages 18 and older ยท Women ยท Updated Sep 18, 2026 ยท NCT06991075Impact of Art Therapy on Self-Reported Pain and Anxiety Scores of Patients Waiting to Be Seen in the Emergency Department
RecruitingHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Sep 17, 2026 ยท NCT05540106State-dependent Interoception, Value-based Decision-making, and Introspection
RecruitingHealthy volunteers welcome
Ages 18 to 55 ยท All sexes ยท Updated Sep 17, 2026 ยท NCT05666726Transcutaneous Vagus Nerve Stimulation in SLE
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 17, 2026 ยท NCT06987565Feasibility Study of a Guided Imagery Therapy Mobile Application for Functional Abdominal Pain Disorders in Children
Recruiting
Ages 7 to 12 ยท All sexes ยท Updated Sep 17, 2026 ยท NCT07222943Clinical and Scientific Assessment of Pain and Painful Disorders
RecruitingObservational studyHealthy volunteers welcome
Ages 12 to 120 ยท All sexes ยท Updated Sep 16, 2026 ยท NCT02707029Nebulized Ketamine to Nebulized Fentanyl for Treating Acute Painful Conditions in the ED
RecruitingPhase 4
Ages 18 to 120 ยท All sexes ยท Updated Sep 15, 2026 ยท NCT06364540Transdiagnostic Cognitive Biomarkers
RecruitingHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Sep 15, 2026 ยท NCT04864080Brief Mindfulness Intervention for Pain Before an In-clinic Orthopedic Procedure
Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 15, 2026 ยท NCT06471075Vagus Nerve Stimulation(VNS) As Treatment For Fibromyalgia Patients
Recruiting
Ages 18 to 80 ยท All sexes ยท Updated Sep 14, 2026 ยท NCT06009159Post-stroke Pain tAN-fMRI
Recruiting
Ages 18 to 80 ยท All sexes ยท Updated Sep 11, 2026 ยท NCT07144436RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain
RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Sep 11, 2026 ยท NCT01719055Massage, Oncology, Pain, Anxiety, Feasibility
Recruiting
Ages 18 to 85 ยท Women ยท Updated Sep 10, 2026 ยท NCT07502157Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE)
RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Sep 10, 2026 ยท NCT07210515Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection
Recruiting
Ages 40 and older ยท All sexes ยท Updated Sep 4, 2026 ยท NCT07804446High Potency Cannabis: Acute and Protracted Effects
RecruitingPhase 1Healthy volunteers welcome
Ages 21 to 55 ยท All sexes ยท Updated Sep 4, 2026 ยท NCT06859723Trans-arterial Embolization for the Treatment of Facet Pain Due to Facet Arthropathy
Recruiting
Ages 18 to 85 ยท All sexes ยท Updated Sep 1, 2026 ยท NCT06965452Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold (RMS) System in Subjects With Coronary Artery Lesions
Recruiting
Ages 18 to 80 ยท All sexes ยท Updated Aug 31, 2026 ยท NCT07258290MDMA-assisted Therapy for Fibromyalgia
RecruitingEarly phase 1
Ages 21 to 65 ยท All sexes ยท Updated Aug 26, 2026 ยท NCT06066853From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.