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Pain clinical trials recruiting in the U.S.
203 studies for Pain are recruiting participants at sites across the United States.
Pain is a feeling triggered in the nervous system. You may feel it as a prick, tingle, sting, burn, or ache. Read about the causes and what can help.
Cities with the most studies
- Boston, MA15 studies
- Durham, NC14 studies
- Washington, DC13 studies
- New York City, NY13 studies
- New Haven, CT10 studies
- Houston, TX9 studies
- San Diego, CA9 studies
- Pittsburgh, PA9 studies
- Los Angeles, CA9 studies
- Chicago, IL8 studies
- Salt Lake City, UT8 studies
- Seattle, WA7 studies
- Atlanta, GA7 studies
- St. Louis, MO6 studies
- Baltimore, MD6 studies
- Gainesville, FL6 studies
- San Antonio, TX5 studies
- Cincinnati, OH5 studies
- Greenburgh, NY5 studies
- Philadelphia, PA5 studies
- Phoenix, AZ4 studies
- East Norwalk, CT4 studies
- Charleston, SC4 studies
- Birmingham, AL4 studies
- Tallahassee, FL4 studies
- New Rochelle, NY4 studies
- Edison, NJ4 studies
- Mountain View, CA4 studies
- Indianapolis, IN4 studies
- Minneapolis, MN3 studies
- Richmond, VA3 studies
- Staten Island, NY3 studies
- Cleveland, OH3 studies
- Charlottesville, VA3 studies
- Tulsa, OK3 studies
- Aurora, CO3 studies
- Austin, TX3 studies
- San Francisco, CA3 studies
- Miami, FL3 studies
- Orlando, FL3 studies
By state
- Alabama5 studies
- Arizona4 studies
- California30 studies
- Colorado7 studies
- Connecticut11 studies
- Delaware4 studies
- District of Columbia7 studies
- Florida21 studies
- Georgia11 studies
- Illinois11 studies
- Indiana4 studies
- Kansas3 studies
- Maryland13 studies
- Massachusetts16 studies
- Michigan6 studies
- Minnesota4 studies
- Missouri5 studies
- New Jersey9 studies
- New York27 studies
- North Carolina19 studies
- Ohio11 studies
- Oklahoma3 studies
- Oregon3 studies
- Pennsylvania12 studies
- South Carolina5 studies
- Tennessee6 studies
- Texas18 studies
- Utah8 studies
- Virginia7 studies
- Washington9 studies
- Wisconsin4 studies
Recently updated studies
Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE)
RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Nov 13, 2026 ยท NCT07210515RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain
RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Nov 13, 2026 ยท NCT01719055Transforming Care for Individuals With Childhood-onset Systemic Lupus Erythematosus
Recruiting
Ages 12 to 22 ยท All sexes ยท Updated Nov 13, 2026 ยท NCT06232304Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold (RMS) System in Subjects With Coronary Artery Lesions
Recruiting
Ages 18 to 80 ยท All sexes ยท Updated Nov 12, 2026 ยท NCT07258290Impact of the NeuroCuple Device on Pain Management After Cesarean Delivery
Recruiting
Ages 18 and older ยท Women ยท Updated Nov 12, 2026 ยท NCT07185425Neural and Psychological Mechanisms of Pain Perception
RecruitingHealthy volunteers welcome
Ages 18 to 50 ยท All sexes ยท Updated Nov 9, 2026 ยท NCT02446262Evaluating Intranasal Oxytocin (TNX-1900) for Pain Relief and Recovery After Pituitary Surgery
RecruitingPhase 2
Ages 30 to 75 ยท All sexes ยท Updated Nov 6, 2026 ยท NCT07730294Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery
RecruitingPhase 1Healthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Nov 6, 2026 ยท NCT06767566The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery
RecruitingPhase 4
Ages 18 and older ยท All sexes ยท Updated Nov 2, 2026 ยท NCT07224711Trans-arterial Embolization for the Treatment of Facet Pain Due to Facet Arthropathy
Recruiting
Ages 18 to 85 ยท All sexes ยท Updated Oct 30, 2026 ยท NCT06965452VR and Cooled Genicular Nerve Radio Frequency Ablation for Chronic Knee Pain
Recruiting
Ages 18 and older ยท All sexes ยท Updated Oct 29, 2026 ยท NCT06336447Dry Needling in Multiple Sclerosis
Recruiting
Ages 18 to 80 ยท All sexes ยท Updated Oct 29, 2026 ยท NCT07615725A Study of Cebranopadol for Opioid Withdrawal Symptoms in Adults With Chronic Pain
RecruitingPhase 2
Ages 18 to 65 ยท All sexes ยท Updated Oct 23, 2026 ยท NCT07874620Behavioral Economic & Staffing Strategies in the ICU
Recruiting
Ages 19 and older ยท All sexes ยท Updated Oct 23, 2026 ยท NCT06184945An Open-Label, Safety and Efficacy Study of Cebranopadol in Participants With Acute Pain With Surgical or Non-Surgical Origin
RecruitingPhase 3
Ages 18 to 75 ยท All sexes ยท Updated Oct 23, 2026 ยท NCT07845071This Study is Comparing Pain Outcomes After Urethral Bulking When Participants Are Randomized to Two Different Pain Medication Regimens.
RecruitingPhase 4
Ages 18 and older ยท Women ยท Updated Oct 22, 2026 ยท NCT07889687Acute Cryotherapy on Musculoskeletal Function and Biomarkers
RecruitingHealthy volunteers welcome
Ages 18 to 30 ยท All sexes ยท Updated Oct 22, 2026 ยท NCT07211412Cannabidiol in Opioid Use Disorder and Chronic Pain With Buprenorphine
RecruitingEarly phase 1
Ages 18 to 70 ยท All sexes ยท Updated Oct 21, 2026 ยท NCT07886606Morphine or Ketamine for Analgesia
RecruitingPhase 3
Ages 6 to 17 ยท All sexes ยท Updated Oct 20, 2026 ยท NCT06835504Sociocultural & Biobehavioral Influences on Pain Expression and Assessment
RecruitingHealthy volunteers welcome
Ages 18 to 60 ยท All sexes ยท Updated Oct 20, 2026 ยท NCT03258580Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI
Recruiting
Ages 18 and older ยท All sexes ยท Updated Oct 16, 2026 ยท NCT05492188Anesthetics and Analgesics in Children
RecruitingObservational study
6 Months โ 17 Years ยท All sexes ยท Updated Oct 16, 2026 ยท NCT03427736Phase 3, Open-Label Extension Study of AMBTX-01 (Neridronate) for Complex Regional Pain Syndrome Type 1
RecruitingPhase 3
Ages 18 and older ยท All sexes ยท Updated Oct 16, 2026 ยท NCT07857733A Study to Evaluate the Feasibility of a Physiologic Biomarker to Assess Pain and Other Sensory Problems Using Pupillometry in Participants With Neurofibromatosis Type 1 (NF1)
Recruiting
Ages 1 to 120 ยท All sexes ยท Updated Oct 16, 2026 ยท NCT06507748Options for Pain Management Using Nonpharmacological Strategies
Recruiting
Ages 18 and older ยท All sexes ยท Updated Oct 15, 2026 ยท NCT05563792From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.