Home › Congenital Heart Defects › NCT04299828
Evaluation of Pro-Inflammatory Leukocyte Activity in Patients Undergoing Cardiac Surgery
Who can join
All ages · All sexes
Full eligibility criteria
Inclusion Criteria: * Patients (all ages) undergoing complex cardiac surgical procedures with CPB. Exclusion Criteria: * undergoing an emergent procedure and do not have more than 1 hour ahead of time to review the consent * patient in a moribund condition American Society of Anesthesiology (ASA 5) -patient with a hematological and/or oncological disease * Jehovah witnesses.
About the study
The goal of this proposal is to prospectively collect data from a series of 200 patients (all ages) undergoing complex cardiac surgical procedures involving cardiopulmonary bypass (CPB) to:
1. Measure the number of blood activated circulating monocytes before, during and after cardiac surgery and serum GABA and pro-inflammatory cytokine levels 2. Understand the correlation between GABA and inflammatory cytokines (and/or activated monocytes) and 3. Assess the correlation between thrombosis and monocyte activation in patients undergoing cardiac surgery under CPB and at risk of thrombosis.
What is being tested
- Discarded blood samples (other)
Sponsor: Boston Children's Hospital · Participants: 100 · Started: May 31, 2022
Contact the study team
- Koichi Yuki, MD · Phone: 617-355-6225
- Rachel Bernier · Phone: 857-218-5348
Official record on ClinicalTrials.gov — NCT04299828
Locations in the U.S.
| Massachusetts | Boston Children's Hospital, Boston |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.