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Congenital Heart Defects clinical trials recruiting in the U.S.
50 studies for Congenital Heart Defects are recruiting participants at sites across the United States.
Congenital heart defects, problems with the structure of the heart, are the most common type of birth defect. Learn about diagnosis and treatment.
Cities with the most studies
- Columbus, OH9 studies
- New York City, NY9 studies
- Boston, MA8 studies
- Rochester, MN8 studies
- Los Angeles, CA8 studies
- Atlanta, GA6 studies
- Salt Lake City, UT6 studies
- Cincinnati, OH6 studies
- Cleveland, OH4 studies
- Durham, NC4 studies
- Ann Arbor, MI4 studies
- Aurora, CO4 studies
- Washington, DC3 studies
- Philadelphia, PA3 studies
- Seattle, WA3 studies
- Mountain View, CA3 studies
- Madison, WI3 studies
- Houston, TX3 studies
- Chicago, IL3 studies
- San Diego, CA3 studies
- Phoenix, AZ3 studies
- St. Louis, MO3 studies
- Kansas City, MO3 studies
- Memphis, TN3 studies
By state
- Arizona3 studies
- California13 studies
- Colorado4 studies
- Florida3 studies
- Georgia6 studies
- Illinois3 studies
- Kentucky3 studies
- Maryland4 studies
- Massachusetts8 studies
- Michigan5 studies
- Minnesota8 studies
- Missouri3 studies
- New York10 studies
- North Carolina4 studies
- Ohio18 studies
- Pennsylvania5 studies
- South Carolina3 studies
- Tennessee5 studies
- Texas4 studies
- Utah6 studies
- Washington3 studies
- Wisconsin3 studies
Recently updated studies
Skin Pigment/Pulse Oximeter in Congenital Heart Disease (CHD)
RecruitingObservational study
Up to age 18 · All sexes · Updated Sep 25, 2026 · NCT06575270Starlight Cardiovascular Lifeline Ductus Arteriosus Stent IDE Study
Recruiting
1 Minute – 6 Months · All sexes · Updated Sep 14, 2026 · NCT07114718BOND: Direct Breastfeeding to Enhance Maternal and Infant Health in Congenital Heart Disease
Recruiting
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07582848Prenatally-initiated Psychological Intervention for Mothers of Infants With Congenital Heart Disease (CHD)
Recruiting
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07582861Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging
RecruitingObservational studyHealthy volunteers welcome
Ages 7 to 100 · All sexes · Updated Sep 8, 2026 · NCT03581318Fontan Associated Liver Disease and the Evaluation of Biomarkers for Disease Severity Assessment
RecruitingObservational study
Ages 18 to 100 · All sexes · Updated Sep 3, 2026 · NCT05213598Continuous vs Intermittent Ketorolac for Pain Control in Peds CV Surgery
RecruitingPhase 4
3 Months – 59 Months · All sexes · Updated Aug 12, 2026 · NCT04040452Cord Clamping Among Neonates With Congenital Heart Disease
Recruiting
37 Weeks – 42 Weeks · All sexes · Updated Aug 12, 2026 · NCT06153459Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System
RecruitingPhase 2
Ages 0 to 16 · All sexes · Updated Aug 10, 2026 · NCT06080074Autus Valve Continued Access Study (CAS)
Recruiting
18 Months – 16 Years · All sexes · Updated Aug 10, 2026 · NCT07466745NO During CPB in Neonates to Reduce Risk of AKI
RecruitingPhase 3
1 Day – 31 Days · All sexes · Updated Aug 5, 2026 · NCT04216927Longitudinal Validation of CIRC Technologies
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT07081711Examining Genetic Factors That Affect the Severity of 22q11.2 Deletion Syndrome
RecruitingObservational study
All ages · All sexes · Updated Jul 29, 2026 · NCT00556530HFNC vs NIPPV Following Extubation
Recruiting
Up to age 1 · All sexes · Updated Jul 14, 2026 · NCT05869825PRecision Integrated Saturation Monitor
RecruitingObservational study
0 Months – 12 Months · All sexes · Updated Jul 7, 2026 · NCT07686341Molecular Genetics of Heterotaxy and Related Congenital Heart Defects
RecruitingObservational study
All ages · All sexes · Updated Jun 22, 2026 · NCT02432079Dynamic Critical Congenital Heart Screening With Addition of Perfusion Measurements
RecruitingHealthy volunteers welcome
0 Minutes – 21 Days · All sexes · Updated Jun 18, 2026 · NCT05637814Congenital Heart Disease Physical Activity Lifestyle Study V.2
Recruiting
Ages 15 to 25 · All sexes · Updated Jun 1, 2026 · NCT06003023Application of a Clinical Decision Support System to Reduce Mechanical Ventilation Duration After Cardiac Surgery in Children
RecruitingObservational study
1 Day – 12 Years · All sexes · Updated May 12, 2026 · NCT05687292Development of CIRC Technologies
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated May 8, 2026 · NCT05654272Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development
RecruitingObservational study
Up to age 20 · All sexes · Updated May 6, 2026 · NCT00243776Implementation of an Accessible Healthcare Model (ACHD STRONG): Comparing Nurse and Physician Lead Healthcare Transition Education in a RE-AIM Framework
Recruiting
Ages 12 to 26 · All sexes · Updated May 5, 2026 · NCT07559253A Study of Invasive Hemodynamic for MACHD Registry
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated May 5, 2026 · NCT05849025Fontan Fitness Trial
Recruiting
Ages 10 to 17 · All sexes · Updated Apr 13, 2026 · NCT06918795Genetics of Congenital Heart Disease
RecruitingObservational studyHealthy volunteers welcome
All ages · All sexes · Updated Apr 7, 2026 · NCT01192048From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.