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Congenital Heart Defects clinical trials recruiting in the U.S.

50 studies for Congenital Heart Defects are recruiting participants at sites across the United States.

Congenital heart defects, problems with the structure of the heart, are the most common type of birth defect. Learn about diagnosis and treatment.

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Recently updated studies

Skin Pigment/Pulse Oximeter in Congenital Heart Disease (CHD)

RecruitingObservational study
Up to age 18 · All sexes · Updated Sep 25, 2026 · NCT06575270

Starlight Cardiovascular Lifeline Ductus Arteriosus Stent IDE Study

Recruiting
1 Minute – 6 Months · All sexes · Updated Sep 14, 2026 · NCT07114718

BOND: Direct Breastfeeding to Enhance Maternal and Infant Health in Congenital Heart Disease

Recruiting
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07582848

Prenatally-initiated Psychological Intervention for Mothers of Infants With Congenital Heart Disease (CHD)

Recruiting
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07582861

Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging

RecruitingObservational studyHealthy volunteers welcome
Ages 7 to 100 · All sexes · Updated Sep 8, 2026 · NCT03581318

Fontan Associated Liver Disease and the Evaluation of Biomarkers for Disease Severity Assessment

RecruitingObservational study
Ages 18 to 100 · All sexes · Updated Sep 3, 2026 · NCT05213598

Continuous vs Intermittent Ketorolac for Pain Control in Peds CV Surgery

RecruitingPhase 4
3 Months – 59 Months · All sexes · Updated Aug 12, 2026 · NCT04040452

Cord Clamping Among Neonates With Congenital Heart Disease

Recruiting
37 Weeks – 42 Weeks · All sexes · Updated Aug 12, 2026 · NCT06153459

Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System

RecruitingPhase 2
Ages 0 to 16 · All sexes · Updated Aug 10, 2026 · NCT06080074

Autus Valve Continued Access Study (CAS)

Recruiting
18 Months – 16 Years · All sexes · Updated Aug 10, 2026 · NCT07466745

NO During CPB in Neonates to Reduce Risk of AKI

RecruitingPhase 3
1 Day – 31 Days · All sexes · Updated Aug 5, 2026 · NCT04216927

Longitudinal Validation of CIRC Technologies

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT07081711

Examining Genetic Factors That Affect the Severity of 22q11.2 Deletion Syndrome

RecruitingObservational study
All ages · All sexes · Updated Jul 29, 2026 · NCT00556530

HFNC vs NIPPV Following Extubation

Recruiting
Up to age 1 · All sexes · Updated Jul 14, 2026 · NCT05869825

PRecision Integrated Saturation Monitor

RecruitingObservational study
0 Months – 12 Months · All sexes · Updated Jul 7, 2026 · NCT07686341

Molecular Genetics of Heterotaxy and Related Congenital Heart Defects

RecruitingObservational study
All ages · All sexes · Updated Jun 22, 2026 · NCT02432079

Dynamic Critical Congenital Heart Screening With Addition of Perfusion Measurements

RecruitingHealthy volunteers welcome
0 Minutes – 21 Days · All sexes · Updated Jun 18, 2026 · NCT05637814

Congenital Heart Disease Physical Activity Lifestyle Study V.2

Recruiting
Ages 15 to 25 · All sexes · Updated Jun 1, 2026 · NCT06003023

Application of a Clinical Decision Support System to Reduce Mechanical Ventilation Duration After Cardiac Surgery in Children

RecruitingObservational study
1 Day – 12 Years · All sexes · Updated May 12, 2026 · NCT05687292

Development of CIRC Technologies

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated May 8, 2026 · NCT05654272

Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development

RecruitingObservational study
Up to age 20 · All sexes · Updated May 6, 2026 · NCT00243776

A Study of Invasive Hemodynamic for MACHD Registry

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated May 5, 2026 · NCT05849025

Fontan Fitness Trial

Recruiting
Ages 10 to 17 · All sexes · Updated Apr 13, 2026 · NCT06918795

Genetics of Congenital Heart Disease

RecruitingObservational studyHealthy volunteers welcome
All ages · All sexes · Updated Apr 7, 2026 · NCT01192048

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.