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Congenital Heart Defects clinical trials recruiting in the U.S.
48 studies for Congenital Heart Defects are recruiting participants at sites across the United States.
Congenital heart defects, problems with the structure of the heart, are the most common type of birth defect. Learn about diagnosis and treatment.
Cities with the most studies
- Columbus, OH8 studies
- Rochester, MN8 studies
- New York City, NY8 studies
- Los Angeles, CA7 studies
- Cincinnati, OH6 studies
- Boston, MA6 studies
- Atlanta, GA5 studies
- Salt Lake City, UT5 studies
- Mountain View, CA4 studies
- Cleveland, OH4 studies
- Durham, NC3 studies
- Washington, DC3 studies
- Chicago, IL3 studies
- Baltimore, MD3 studies
- Houston, TX3 studies
- Philadelphia, PA3 studies
- Aurora, CO3 studies
- Memphis, TN3 studies
- Madison, WI3 studies
- St. Louis, MO3 studies
- Kansas City, MO3 studies
- Phoenix, AZ3 studies
- Ann Arbor, MI3 studies
By state
- Arizona3 studies
- California12 studies
- Colorado3 studies
- Florida3 studies
- Georgia5 studies
- Illinois3 studies
- Kentucky3 studies
- Maryland5 studies
- Massachusetts6 studies
- Michigan4 studies
- Minnesota8 studies
- Missouri3 studies
- New York9 studies
- North Carolina3 studies
- Ohio17 studies
- Pennsylvania5 studies
- South Carolina3 studies
- Tennessee5 studies
- Texas4 studies
- Utah5 studies
- Wisconsin3 studies
Recently updated studies
Psychological Trauma, Post-Traumatic Stress Disorder, and Resilience in Adults With Congenital Heart Disease
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT06952933iPSC Repository of Pediatric Cardiovascular Disease
RecruitingObservational studyHealthy volunteers welcome
All ages · All sexes · Updated Nov 12, 2026 · NCT05550324Two-Year Study of the Safety and Efficacy of the Second-Generation Tissue Engineered Vascular Grafts
RecruitingPhase 2
All ages · All sexes · Updated Nov 10, 2026 · NCT04467671Butyric Acid Supplementation for Gut Improvement After Cardiac Surgery in Kids
RecruitingPhase 1/2
1 Month – 3 Years · All sexes · Updated Oct 30, 2026 · NCT06882772Starlight Cardiovascular Lifeline Ductus Arteriosus Stent IDE Study
Recruiting
1 Minute – 6 Months · All sexes · Updated Oct 29, 2026 · NCT07114718Implementing Models for Mechanical Circulatory Support Presurgical Assessment in Congenital Heart Disease Treatment
Recruiting
All ages · All sexes · Updated Oct 23, 2026 · NCT03891160Fontan Associated Liver Disease and the Evaluation of Biomarkers for Disease Severity Assessment
RecruitingObservational study
Ages 18 to 100 · All sexes · Updated Oct 13, 2026 · NCT05213598Effect of Sacubitril-Valsartan on Cardiac Structure and Function
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 9, 2026 · NCT06693674Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging
RecruitingObservational studyHealthy volunteers welcome
Ages 7 to 100 · All sexes · Updated Oct 5, 2026 · NCT03581318Skin Pigment/Pulse Oximeter in Congenital Heart Disease (CHD)
RecruitingObservational study
Up to age 18 · All sexes · Updated Sep 25, 2026 · NCT06575270BOND: Direct Breastfeeding to Enhance Maternal and Infant Health in Congenital Heart Disease
Recruiting
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07582848Prenatally-initiated Psychological Intervention for Mothers of Infants With Congenital Heart Disease (CHD)
Recruiting
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07582861Cord Clamping Among Neonates With Congenital Heart Disease
Recruiting
37 Weeks – 42 Weeks · All sexes · Updated Aug 12, 2026 · NCT06153459Continuous vs Intermittent Ketorolac for Pain Control in Peds CV Surgery
RecruitingPhase 4
3 Months – 59 Months · All sexes · Updated Aug 12, 2026 · NCT04040452Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System
RecruitingPhase 2
Ages 0 to 16 · All sexes · Updated Aug 10, 2026 · NCT06080074NO During CPB in Neonates to Reduce Risk of AKI
RecruitingPhase 3
1 Day – 31 Days · All sexes · Updated Aug 5, 2026 · NCT04216927Longitudinal Validation of CIRC Technologies
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT07081711Examining Genetic Factors That Affect the Severity of 22q11.2 Deletion Syndrome
RecruitingObservational study
All ages · All sexes · Updated Jul 29, 2026 · NCT00556530HFNC vs NIPPV Following Extubation
Recruiting
Up to age 1 · All sexes · Updated Jul 14, 2026 · NCT05869825PRecision Integrated Saturation Monitor
RecruitingObservational study
0 Months – 12 Months · All sexes · Updated Jul 7, 2026 · NCT07686341Molecular Genetics of Heterotaxy and Related Congenital Heart Defects
RecruitingObservational study
All ages · All sexes · Updated Jun 22, 2026 · NCT02432079Dynamic Critical Congenital Heart Screening With Addition of Perfusion Measurements
RecruitingHealthy volunteers welcome
0 Minutes – 21 Days · All sexes · Updated Jun 18, 2026 · NCT05637814Congenital Heart Disease Physical Activity Lifestyle Study V.2
Recruiting
Ages 15 to 25 · All sexes · Updated Jun 1, 2026 · NCT06003023Application of a Clinical Decision Support System to Reduce Mechanical Ventilation Duration After Cardiac Surgery in Children
RecruitingObservational study
1 Day – 12 Years · All sexes · Updated May 12, 2026 · NCT05687292Development of CIRC Technologies
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated May 8, 2026 · NCT05654272From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.