CONFIRM: Magnetic Resonance Guided Radiation Therapy

Recruiting

Clinical Onboard Utilization of Image Guided Radiation Therapy With Magnetic Resonance (CONFIRM): A Master Protocol

Who can join

Ages 18 and older · All sexes

Full eligibility criteria

Inclusion Criteria:

* Participants must have histologically or cytologically confirmed malignancy requiring radiation
* Age 18 years of older
* ECOG performance status ≤2 (Karnofsky ≥60%, see Appendix A)
* Ability to understand and the willingness to sign a written informed consent document.
* Any further criteria listed in the specific disease site cohort

Exclusion Criteria

* History of allergic reactions attributed to gadolinium-based IV contrast

  \-- Note: If patient will not receive contrast, this is not applicable and kidney function will not affect eligibility
* Severe claustrophobia or anxiety
* Participants who cannot undergo an MRI
* Any other exclusion criteria listed in the specific disease site cohort

About the study

This research is being done to determine the safety and feasibility of using a type of radiation guided by magnetic resonance imaging (MRI) and chemotherapy to treat patients with gastric and breast cancer. The name of the radiation machine involved in this study is the MRIdian Linear Accelerator.

What is being tested

Viewray MRIdian® Linac (radiation)

Sponsor: Brigham and Women's Hospital · Participants: 70 · Started: May 1, 2021

Contact the study team

Raymond Mak, MD · Phone: 6177328651

Official record on ClinicalTrials.gov — NCT04368702

Locations in the U.S.

Massachusetts

Brigham & Women's Hospital, Boston
Dana Farber Cancer Institute, Boston

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.