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Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women
Who can join
Ages 35 to 70 · Women · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Aged 35-49 or 50-70 years of age who experienced premature (\<40) or early (≤45) menopause * Premenopausal 35-49 years of age * Typical-age menopause (i.e., after 45 years of age), who are between 50-70 years old * Menopause will be confirmed by subject report of amenorrhea for 12 months and serum FSH of \>30 mIU/mL Exclusion Criteria: * Current nicotine/tobacco use within the past six months * Are diabetic or asthmatic * Have diagnosed significant carotid stenosis * Have a history of significant autonomic dysfunction, heart disease, respiratory disease or a severe neurologic condition such as stroke or traumatic brain injury. * Have existing metabolic or endocrine abnormities * Take any heart/blood pressure medications that are determined to interfere with study outcomes * IF the participant is premenopausal AND currently taking OC or other exogenous steroids that are determined to interfere with study outcomes * Females who classify as having early or premature menopause AND are not willing to discontinue OC or MHT in order to complete the study * Are pregnant or breastfeeding
About the study
This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in premature and early menopausal women and aim two will determine mechanisms driving autonomic dysregulation of BP in older menopausal women. The study design outlined below will permit testing of aim one and aim two.
What is being tested
- Microneurography to measure muscle sympathetic nerve activity (MSNA) (diagnostic test)
- Baroreflex sensitivity testing (diagnostic test)
- Sympathoexcitatory Maneuvers (diagnostic test)
- Blood tests (diagnostic test)
Sponsor: University of Minnesota · Participants: 160 · Started: Oct 1, 2019
Contact the study team
- Manda Keller-Ross, PhD, DPT, PT · Phone: 612-625-3175
Official record on ClinicalTrials.gov — NCT04439370
Locations in the U.S.
| Minnesota | University of Minnesota, Minneapolis |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.