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Pathogenesis of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD)

Pathophysiologic Mechanisms Leading to Intrahepatic Fat Accumulation in Obese Youth

Who can join

Ages 12 to 18 · All sexes

Inclusion Criteria:

* Good general health, taking no medication on a chronic basis;
* age 12 to 18 years, in puberty (girls and boys: Tanner stage II-V);
* BMI \>85th for obese cohort;

Exclusion Criteria:

* Baseline creatinine \>1.0 mg; pregnancy;
* the presence of endocrinopathies (e.g. Cushing syndrome);
* cardiac or pulmonary or other significant chronic illness;
* adolescents with a psychiatric disorder or with substance abuse;
* monogenic obesity syndromes;
* use of drugs affecting intrahepatic fat content (e.g.; liraglutide, fish oil, etc.).

About the study

The main aim of the study is to discover the mechanisms underlying the pathophysiology of NAFLD in obese youth.

What is being tested

• Usual diet and physical activity (other)

Sponsor: Yale University · Participants: 260 · Started: Jun 28, 2021

Contact the study team

• Ermena REFUGJATI · Phone: 2032157119

Official record on ClinicalTrials.gov — NCT04634643

Locations in the U.S.

Conditions

• Steatotic Liver Disease

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.