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Mechanistic Interventions and Neuroscience of Dissociation

Who can join

Ages 18 to 65 · All sexes

Inclusion Criteria:

* experience of at least one Diagnostic and Statistical Manual of Mental Disorders (DSM-5) Criterion A trauma (assessed using the Life Events Checklist)
* a score of 7 or higher on the Multiscale Dissociation Inventory (MDI) depersonalization subscale
* willingness to participate in the study

Exclusion Criteria:

* actively psychotic and cognitively compromised individuals (assessed using the Moderate-severe cognitive impairment screening tool (MoCA) will be excluded
* moderate or more severe substance dependence (assessed with the MINI)
* persons with imminent risk of physical violence to self or others

About the study

The purpose of this study is to test the neurophysiological mechanisms of an intervention to reduce symptoms of dissociation in traumatized people. The intervention will be tested in dissociative traumatized people at two sites: Emory University and University of Pittsburgh. The researchers are interested in whether neural networks associated with attentional control and interoceptive awareness can be enhanced in this population. The researchers propose to evaluate whether different body-focused and non-body focused interventions can change these mechanisms.

What is being tested

• Vibration (device)
• Breath Focus (behavioral)
• No Distractions (behavioral)

Sponsor: Emory University · Participants: 350 · Started: Sep 18, 2021

Contact the study team

• Negar Fani, PhD · Phone: 404-712-0354
• Greg Siegle, PhD · Phone: 412-864-3501

Official record on ClinicalTrials.gov — NCT04670640

Locations in the U.S.

Conditions

• Post-Traumatic Stress Disorder

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.