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Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone
Pain Relief After Trapeziectomy Without Opioids: Ibuprofen & Acetaminophen Versus Oxycodone
Who can join
Ages 45 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Undergoing trapeziectomy for thumb osteoarthritis English proficient, Exclusion Criteria: * Pregnancy Current use of opioids Concurrent surgeries (ex. trapeziectomy combined with carpal tunnel release) Inability to complete study forms (education, cognitive ability, mental status, medical status) Allergy or intolerance to Ibuprofen, Acetaminophen and/or Oxycodone Liver or kidney dysfunction, abnormal liver enzymes restricting use of acetaminophen or ibuprofen History of chronic heart failure, upper gastrointestinal bleeding or coagulopathy History of complex regional pain syndrome
About the study
In the US, pain management after surgery for surgical treatment of osteoarthritis at the base of the thumb typically consists of prescription opioids during the early recovery phase. Given the highly addictive nature of prescription opioids, guidelines are being evaluated by hand surgeons to reduce opioid use while still maintaining pain control after surgery. A promising approach is to use non-narcotic medication as the first line of treatment. The purpose of this study is to demonstrate the efficacy of a combination of non-steroidal anti-inflammatory drugs (NSAIDs), ibuprofen and acetaminophen, in comparison to a morphine analogue substance (oxycodone) for pain management in the first 30 days after surgery.
What is being tested
- NSAID capsules (drug)
- Opioid capsule (drug)
Sponsor: Stanford University · Participants: 121 · Started: Dec 27, 2021
Contact the study team
- Deborah Kenney, MS OTR · Phone: 6507217644
Official record on ClinicalTrials.gov — NCT04676802
Locations in the U.S.
| California | Stanford Health Care, Redwood City |
| Utah | University of Utah Health Care, Salt Lake City |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.