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The EBC Recovery Study

Electrophysiologic Biomarkers of Consciousness (EBC) Recovery After Brain Injury

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Inclusion Criteria:

For ABI Participants

* ABI adult (18 years and older) patients who are admitted to the intensive care unit
* Unconscious with Glasgow Coma Scale (GCS) \<8 on presentation and unable to follow bedside commands.
* A negative COVID-19 test on arrival

For Healthy Volunteers:

* 18 years and older

Exclusion Criteria:

For All Participants:

* \<18 years of age
* Pregnant woman
* Patients with cardiac arrest on presentation

About the study

The purpose of this research study to find out if clinically unconscious acute brain injury patients that show brain activation to music and language on electroencephalogram (EEG) (bedside test) have better outcomes and wake up in the future.

What is being tested

• Auditory stimuli (diagnostic test)

Sponsor: University of Miami · Participants: 300 · Started: Jun 18, 2020

Contact the study team

• Ayham Alkhachroum, MD · Phone: (305) 243-3218

Official record on ClinicalTrials.gov — NCT04712591

Locations in the U.S.

Conditions

• Traumatic Brain Injury
• Cerebral Hemorrhage
• Coma

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.