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Traumatic Brain Injury clinical trials recruiting in the U.S.
138 studies for Traumatic Brain Injury are recruiting participants at sites across the United States.
Traumatic brain injury or TBI happens when a bump, blow, or other head injury causes damage to the brain. Treatment and outcome depend on how severe.
Cities with the most studies
- Boston, MA11 studies
- Minneapolis, MN10 studies
- Washington, DC8 studies
- New York City, NY8 studies
- Pittsburgh, PA7 studies
- Cincinnati, OH6 studies
- Baltimore, MD6 studies
- Dallas, TX6 studies
- Philadelphia, PA6 studies
- Portland, OR6 studies
- Seattle, WA5 studies
- Houston, TX5 studies
- Miami, FL5 studies
- Chicago, IL5 studies
- San Diego, CA5 studies
- Boise, ID4 studies
- San Francisco, CA4 studies
- Gainesville, FL4 studies
- Newark, NJ4 studies
- Columbus, OH4 studies
- Detroit, MI4 studies
- Cedar Rapids, IA4 studies
- Durham, NC4 studies
- St. Louis, MO4 studies
- Los Angeles, CA3 studies
- Albuquerque, NM3 studies
- Sacramento, CA3 studies
- Bridgeport, CT3 studies
- San Antonio, TX3 studies
- Lexington, KY3 studies
By state
- California19 studies
- Colorado4 studies
- District of Columbia3 studies
- Florida14 studies
- Idaho4 studies
- Illinois6 studies
- Iowa4 studies
- Kentucky4 studies
- Maryland11 studies
- Massachusetts12 studies
- Michigan5 studies
- Minnesota10 studies
- Missouri4 studies
- New Jersey7 studies
- New Mexico3 studies
- New York12 studies
- North Carolina10 studies
- Ohio13 studies
- Oregon7 studies
- Pennsylvania13 studies
- Texas13 studies
- Virginia3 studies
- Washington6 studies
- Wisconsin4 studies
Recently updated studies
A Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults and for Monitoring the Development of Secondary Events in Patients Diagnosed With Traumatic Brain Injury
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT07455136Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)
Recruiting
Ages 18 to 60 · All sexes · Updated Nov 13, 2026 · NCT06413173Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI)
RecruitingPhase 1
Ages 18 to 55 · All sexes · Updated Nov 12, 2026 · NCT07890337Stimulating Specific Brain Areas (VOP/VIM) With Electricity to Improve Movement and Muscle Control
Recruiting
Ages 18 to 75 · All sexes · Updated Nov 12, 2026 · NCT07056361Carbon Dioxide Administration and Brain Waste Clearance
RecruitingHealthy volunteers welcome
Ages 18 to 82 · All sexes · Updated Nov 12, 2026 · NCT07357090Using Non-invasive Brain Stimulation to Treat Word Finding Difficulty in Chronic Traumatic Brain Injury
Recruiting
Ages 18 to 85 · All sexes · Updated Nov 10, 2026 · NCT06848140Deployment of a Novel National Institute of Neurological Disorders and Stroke Clinical, Biomarker, Imaging, and Modifiers (CBI-M) Classification Framework for Emergency Department Patients With Glasgow Coma Scale 15 Traumatic Brain Injury (PIONEER-Prognosis)
RecruitingObservational study
Ages 18 to 65 · All sexes · Updated Nov 10, 2026 · NCT07858266The PIONEER Comparative Effectiveness Study - Project 2
Recruiting
Ages 18 and older · All sexes · Updated Nov 10, 2026 · NCT07829107Smartphone Enabled Detection of Cognitive Motor Dissociation in the ICU
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT07917728Sleep to Predict Recovery In Unconscious Patients With Acute Brain Injury
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 2, 2026 · NCT07794605CoMind Early Feasibility Study
RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT06368648Cortical Spreading Depolarization After Severe Traumatic Brain Injury
RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 29, 2026 · NCT03321370Predict Severe Traumatic Brain Injury
RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 29, 2026 · NCT06966713High Intensity Step Training After Traumatic Brain Injury
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 21, 2026 · NCT05702138Overground Virtual Reality (VR) Gait Rehabilitation for Traumatic Brain Injury (TBI)
Recruiting
Ages 18 and older · All sexes · Updated Oct 15, 2026 · NCT07038889Control Network Neuromodulation to Enhance Cognitive Training in Complex Traumatic Brain Injury
Recruiting
Ages 18 to 59 · All sexes · Updated Oct 14, 2026 · NCT05236010HBOT Effects on First Responders' Cognition and Well-Being
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Oct 1, 2026 · NCT07852728Hyperbaric Oxygen Therapy for Veterans With TBI and PCS: A Biomarker Study
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Sep 30, 2026 · NCT07849465Non-Invasive Monitoring Methods in Patients With Acute Brain Injury
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06504238Transcutaneous Auricular Neurostimulation for ICU Patients With Traumatic Brain Injury
Recruiting
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT06467708Treating Mild Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation
Recruiting
Ages 18 to 75 · All sexes · Updated Sep 29, 2026 · NCT04869059Depth Electrode Cortical Reverberation Monitoring After Traumatic Brain Injury
Recruiting
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07842458Comparison of Two Group Wellness Interventions for Individuals With Neurologic Conditions and Their Support Persons
Recruiting
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05048966Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function
RecruitingHealthy volunteers welcome
Ages 18 to 80 · All sexes · Updated Sep 18, 2026 · NCT07056348Pilot Study of BCAA on Sleep
Recruiting
Ages 18 to 89 · All sexes · Updated Sep 17, 2026 · NCT03990909From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.