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Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

Corticostriatal Neurophysiology in Parkinson's Disease Cognitive Impairment

Who can join

Ages 40 and older · All sexes

Inclusion criteria:

* Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center
* Planned clinical electrode trajectory that contacts caudate
* Age greater than or equal to 40
* Diagnosis of Parkinson's disease
* Able to participate in intraoperative testing
* English speaking

Exclusion criteria:

* Age less than 40
* Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)
* Movement disorder other than Parkinson's disease

About the study

The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.

What is being tested

• Neurophysiology recordings (other)
• Neural stimulation (other)

Sponsor: Vanderbilt University Medical Center · Participants: 75 · Started: Jun 2, 2021

Contact the study team

• Lucas Chang, BA · Phone: 615-421-3046
• Sarah Bick, MD · Phone: 615-343-9822

Official record on ClinicalTrials.gov — NCT04715984

Locations in the U.S.

Conditions

• Parkinson's Disease

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.