Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty
Identifying Modifiable PAtient Centered Therapeutics Frailty: An Observational Cohort Study
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Adult patients admitted to the Surgical, Cardiothoracic or Neuro ICU * ICU stay longer than 24 hours Exclusion Criteria: * Patients with muscular or mitochondrial diseases affecting muscle quality or mass * Preexisting paralysis * Absence of lower limbs * Ongoing discussions about goals of care * Transfers from a skilled nursing facility * Children under the age of 18
About the study
Frailty, the decline in physical and cognitive reserves leading to vulnerability to stressors is increasingly being recognized as a public health concern. Although multiple measures exist that can identify frail patients, very little is known about how or when to intervene. Sarcopenia, or the degree of muscle wasting, is closely correlated to frailty and patient outcomes. This is a prospective cohort study of critically ill patients to identify modifiable risk factors of sarcopenia, as potential targets to reduce frailty.
What is being tested
- Ultrasound (diagnostic test)
- Biomarker Analysis (diagnostic test)
- Frailty Index (other)
Sponsor: University of California, Los Angeles · Participants: 250 · Started: Sep 22, 2023
Contact the study team
- Jennifer Scovotti, MA · Phone: 3102064484
Official record on ClinicalTrials.gov — NCT04717869
Locations in the U.S.
| California | Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine, Los Angeles |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.