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Investigating Inhibitory Control Networks in Parkinson's Disease
Who can join
Ages 18 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Eligible for surgery based on multi-disciplinary consensus review * Have a diagnosis of Parkinson's disease or Essential Tremor * Have a diagnosis of medically-refractory movement disorder (Parkinson's disease, Essential Tremor, or dystonia) * Willingness to participate in the paradigms described in the protocol Exclusion Criteria: * Inability to provide full and informed consent * Age younger than 18 * Are not able to participate in study-related activities * History of prior ischemic/hemorrhagic stroke, subdural hemorrhage, or seizure
About the study
The purpose of this study is to investigate the brain activity associated with non-motor symptoms of movement disorders, including Parkinson's disease and essential tremor. These movement disorders commonly have significant non-motor features also, including depression, cognitive impairment, decreased attention, and slower processing speeds. The investigators are interested in the brain activity associated with these symptoms, and perform recordings of the surface of the brain, in addition to the typical recordings the investigators perform, during routine deep brain stimulation (DBS) surgery.
What is being tested
- Procedure/Surgery: Response Inhibition and Deep Brain Stimulation in Parkinson's disease (other)
Sponsor: University of Alabama at Birmingham · Participants: 140 · Started: Apr 1, 2021
Contact the study team
- Nicole Bentley, MD · Phone: 205-975-0011
Official record on ClinicalTrials.gov — NCT04735458
Locations in the U.S.
| Alabama | University of Alabama at Birmingham, Birmingham |
Conditions
From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.