Home › Pulmonary Hypertension › NCT04756076
Study Roles of Heavy Metals and Essential Metal Dyshomeostasis in Pulmonary Arterial Hypertension Patients
Who can join
Ages 18 and older · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * All patients with the diagnosis of pulmonary hypertension * Agree to the study protocol * Healthy volunteers * Age, gender matched controls Exclusion Criteria: * Younger than 18 years * Refusal to participate
About the study
Investigators plan to recruit 50 PAH patients from UofL PAH Clinic, with various degrees of severity (25 intermediate risk patients and 20 high risk patients) and 10 age and gender matched controls. PAH patients are evaluated at least every 6 months by the PAH Clinic and blood/urine samples will be obtained at each office visit. Blood, plasma and urine samples will be used to measure 31 metal levels including heavy metals (cadmium, arsenic, cobalt, lead etc.) and essential metals (calcium, copper, iron, zinc, potassium etc.) by the with ICP-MS via the service of ITEMFC. Interactions among the 31 metals in PAH patients, metal concentration differences between intermediate risk PAH, high risk PAH and control groups, the correlation between metal concentrations and the etiology, severity, duration, treatment, and progression of PAH/RV dysfunction over 12 months will be analyzed by CIEHS Biostatistics and Informatics Facility Core.
What is being tested
- Metal level measurements (diagnostic test)
Sponsor: Jiapeng Huang · Participants: 110 · Started: Dec 2, 2020
Contact the study team
- Jiapeng Huang, MD, PhD · Phone: 5028528157
Official record on ClinicalTrials.gov — NCT04756076
Locations in the U.S.
| Kentucky | University of Louisville Health, Louisville |
Conditions
From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.