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The Pediatric ALL Evaluation and Trial

The Pediatric ALL Evaluation and Trial: A Randomized, Controlled Trial

Who can join

Up to age 18 · All sexes · Healthy volunteers welcome

Inclusion Criteria:

* Age 18 and under
* Surgery within 6 months of injury
* Undergoing primary ACL reconstruction without previous injury or surgery
* Quadriceps tendon autograft ACL reconstruction
* Closing or closed physes

Exclusion Criteria:

* Over 18 years old
* Previous ipsilateral knee injury or surgery
* Neuromuscular or developmental disorders affecting knee anatomy, cognition, or neuromuscular control
* Other concomitant ligament reconstruction aside from the ALL (i.e., MCL, PCL, PLC)
* Revision ACL reconstruction
* ACL reconstruction with graft other than quadriceps tendon
* IT band (modified MacIntosh) ACL reconstruction
* A cartilage lesion requiring anything more than debridement
* Open physes requiring both femoral and tibial physeal-sparing technique

About the study

The overall aim of this multicenter RCT is to determine whether concomitant ALL reconstruction in children undergoing and ACL reconstruction will longitudinally result in a lower rate of graft failure than ACL reconstruction alone.

What is being tested

• Patients will be randomized into one of two study arms: (1) concomitant ACL and ALL reconstruction or (2) ACL reconstruction alone. (procedure)

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago · Participants: 240 · Started: Apr 28, 2021

Contact the study team

• Amanda Kass · Phone: 312-227-1267
• Neeraj Patel, MD · Phone: 312-227-6190

Official record on ClinicalTrials.gov — NCT04825587

Locations in the U.S.

Conditions

• Anterior Cruciate Ligament Injuries

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.